SrbA (
sRNA regulator of biofilms A) is a
small regulatory non-coding RNA identified in pathogenic ''
Pseudomonas aeruginosa
''Pseudomonas aeruginosa'' is a common encapsulated, gram-negative, aerobic–facultatively anaerobic, rod-shaped bacterium that can cause disease in plants and animals, including humans. A species of considerable medical importance, ''P. aerugi ...
'.'' It is important for
biofilm
A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface. These adherent cells become embedded within a slimy extracellular matrix that is composed of extracellular ...
formation and pathogenicity. Bacterial strain with deleted SrbA had reduced biofilm mass. As the ability to form biofilms can contribute to the ability a pathogen to thrive within the host, the ''
C. elegans
''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' (r ...
'' hosts infected with the srbA deleted strain displayed significantly lower mortality rate than the wild-type strain. However, the deletion of srbA had no effect on growth or antibiotic resistance in ''P. aeruginosa''.
See also
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NrsZ small RNA
NrsZ (nitrogen regulated small RNA) is a bacterial small RNA found in the opportunistic pathogen ''Pseudomonas aeruginosa'' PAO1. Its transcription is induced during nitrogen limitation by the NtrB/C two-component system (an important regulator of ...
*
''Pseudomonas'' sRNA
*
AsponA antisense RNA AsponA is a small asRNA transcribed antisense to the penicillin-binding protein 1A gene called ''ponA.'' It was identified by RNAseq and the expression was validated by 5' and 3' RACE experiments in '' Pseudomanas aeruginosa''. ''AsponA'' express ...
References
Non-coding RNA
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