The SraL RNA ('sra' for small RNA), also known as RyjA, is a small non-coding RNA discovered ''in E. coli'',
and later in ''
Salmonella Tiphimurium.''
This ncRNA was found to be expressed only in
stationary phase.
It may possibly play a role in ''Salmonella'' virulence.
The major stationary phase regulator
RpoS
The gene ''rpoS'' (RNA polymerase, sigma S, also called katF) encodes the sigma factor ''sigma-38'' (σ38, or RpoS), a 37.8 kD protein in ''Escherichia coli''. Sigma factors are proteins that regulate transcription in bacteria. Sigma factors can ...
is transcriptionally regulating SraL and directly binds to the sraL gene promoter. SraL down-regulates the expression of the ribosome-associated chaperone Trigger Factor (TF), which is involved in the folding of the newly synthesised cystolic proteins.
References
Non-coding RNA
{{molecular-cell-biology-stub