The Spring Grove Experiment is a series of
lysergic acid diethylamide
Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...
(LSD) studies performed from 1963 to 1976 on patients with psychotic illnesses at the Spring Grove Clinic in Catonsville, Maryland. These patients were sponsored by a federal agency called the
National Institute of Mental Health
The National Institute of Mental Health (NIMH) is one of 27 institutes and centers that make up the National Institutes of Health (NIH). The NIH, in turn, is an agency of the United States Department of Health and Human Services and is the prima ...
to be part of the first study conducted on the effects of
psychedelic drug
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science o ...
s on people with
schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...
.
Then, the Spring Grove Experiments were adapted to study the effect of LSD and
psychotherapy
Psychotherapy (also psychological therapy, talk therapy, or talking therapy) is the use of psychological methods, particularly when based on regular personal interaction, to help a person change behavior, increase happiness, and overcome pro ...
on patients including alcoholics,
heroin
Heroin, also known as diacetylmorphine and diamorphine among other names, is a potent opioid mainly used as a recreational drug for its euphoric effects. Medical grade diamorphine is used as a pure hydrochloride salt. Various white and brow ...
addicts,
neurotics
Neurotic may refer to:
* Neurosis, a class of functional mental disorders involving distress but neither delusions nor hallucinations
* Neuroticism, a fundamental personality trait characterized by anxiety, moodiness, worry, envy and jealousy
* T ...
, and terminally-ill cancer patients. The research done was largely conducted by the members of the Research Unit of Spring Grove State Hospital. Significant contributors to the experiments included
Walter Pahnke
Walter Norman Pahnke (Jan 18, 1931 – July 10, 1971) was a minister, physician, and psychiatrist most famous for the "Good Friday Experiment", also referred to as the Marsh Chapel Experiment or the "Miracle of Marsh Chapel".
Pahnke attended Harva ...
,
Albert Kurland, Sanford Unger, Richard Yensen,
Stanislav Grof
Stanislav "Stan" Grof is a Czech-born psychiatrist who has been living in the United States since the 1960s. Grof is one of the principal developers of transpersonal psychology and research into the use of non-ordinary states of consciousness ...
, William Richards, Francesco Di Leo and Oliver Lee McCabe. Later, Spring Grove was rebuilt into the Maryland Psychiatric Research Center, where studies continued to be performed for the advancement of psychiatric research.
This study on LSD is the largest study on psychedelic drugs to date.
Historical context
In 1943,
Albert Hofmann
Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesiz ...
discovered the hallucinogenic effects of LSD that led to an altered state of consciousness.
In 1947, Gion Condrau and
Arthur Stoll
Arthur Stoll (8 January 1887 – 13 January 1971) was a Swiss biochemist.
Education and career
The son of a teacher and school headmaster, he studied chemistry at the ETH Zurich, with a PhD in 1911, where he studied with Richard Willstätter. ...
observed that people diagnosed as "
psychotics
Psychosis is a condition of the mind that results in difficulties determining what is real and what is not real. Symptoms may include delusions and hallucinations, among other features. Additional symptoms are incoherent speech and behavior t ...
" had a stronger tolerance for LSD and that the effects of the drug were similar to the symptoms expressed by psychotics themselves.
In the late 1940s, English researcher Mayer-Gross found connections between schizophrenia and behaviors produced by LSD administration.
In 1950, AK Busch and WC Johnson determined LSD's stimulative effects and first made the connection of LSD and its potential use in psychotherapy.
In 1951, De Giacomo confirmed that when subjects with schizophrenia were given large dosages of LSD by mouth, they experienced a state of catatonia.
He also stated that psychotic patients were more tolerant than healthy patients to LSD, and required higher dosages to produce responses.
In 1953, D.W. Liddell and H. Weil-Malherbe studied the effects of LSD on mental processes and adrenaline in the blood and began characterizing the behaviors resulting from LSD administration to patients. They found that "depressive patients,"
experienced enhanced symptoms, becoming more depressed; while patients with schizophrenia experienced
catatonic
Catatonia is a complex neuropsychiatric behavioral syndrome that is characterized by abnormal movements, immobility, abnormal behaviors, and withdrawal. The onset of catatonia can be acute or subtle and symptoms can wax, wane, or change during ...
, or altered, states. They also found that after administering LSD through the patients' veins, adrenaline levels would fluctuate by rising, dropping, and rising, while blood glucose remained unaffected by the drug. Their method of administering LSD through the veins of patients with schizophrenia was adopted in later studies.
In 1953, Canadian researchers studied the use of LSD to treat alcoholism. It was found that those who treated their condition with LSD recovered more quickly than those who used a conventional treatment.
In the early 1960s in Psychedelic Research Institute in Prague, Czechoslovakia, Stanislav Grof tested the value of LSD in treatment of psychologically ill patients. His goal was to observe the effect of psychedelics on the psychology of terminally-ill cancer patients.
Grof would later be involved in research at the Spring Grove Clinic.
Psychedelic research at Spring Grove
Experiments at Spring Grove Clinic began in the 1950s at the
Spring Grove State Hospital
Spring Grove Hospital Center, formerly known as Spring Grove State Hospital, is a psychiatric hospital located in the Baltimore, Maryland, suburb of Catonsville.
Founded in 1797 as a general medical and psychiatric retreat, Spring Grove Mental ...
, however the first official Spring Grove Experiment began in 1963. Many of the patients who took part in these experiments federally funded by the
National Institute of Mental Health
The National Institute of Mental Health (NIMH) is one of 27 institutes and centers that make up the National Institutes of Health (NIH). The NIH, in turn, is an agency of the United States Department of Health and Human Services and is the prima ...
(NIMH) were admitted against their own wishes.
Over the course of the experiments, over 700 people were treated with LSD; however, no more than six to eight patients were treated at a time.
Preliminary experiments
The first psychedelic experiment at the Spring Grove clinic took place in 1955. A small team of researchers including
Albert Kurland, Louis S. Cholden, and Charles Savage
set out to analyze the reaction resulting from the administration of LSD to patients with chronic schizophrenia. In an attempt to conduct this study with scientific proof, the researchers administered LSD using a
double blind procedure. By the end of the first study, the researchers determined that it was not possible to administer LSD using a double blind, because it was obvious to the researchers who had been given LSD.
It was, however, found that LSD was unique in its effects on consciousness and unlike other drugs, resulted in rapid tolerance in patients. They determined the effects of LSD to include intense hallucinations and illusions. This work established the foundation for future experiments.
The Spring Grove Experiment: alcoholism and LSD
In 1963, after observing the initial effects of LSD, the first official experiment included in the "Spring Grove Experiment" series began. This experiment was performed on 69 alcoholic patients. Enthusiastic and hopeful about the possible results of LSD treatment, a team of researchers under Dr. Albert Kurland, Director of Research at State of Maryland Department of Mental Hygiene at the time, Dr. Charles Savage, Director of Research at Spring Grove Hospital, Dr. Shaffer, and Dr. Sanford Unger
performed experiments to test LSD with psychotherapy as treatment for alcoholic patients. This work was backed by the State Hospital Alcoholic Rehabilitation Unit.
The findings of this experiment were published four years later in 1967.
According to the experimenters themselves, the rationale for using psychedelics to treat alcoholic patients is in the "clinical picture" presented in the features of alcoholic patients. Various personality types such as "neurotic, psychopathic, and schizoid" were thought to have a vulnerability that led to their addiction to alcohol. These individuals were perceived as having a weakened ability to "handle psychological stress, tensions, and frustrations."
They also believed that LSD would allow psychiatrists to open memories and emotions to restore and alter the brain and mind, but only under certain conditions.
The Spring Grove experiment was conducted in Cottage 13, a building on the Spring Grove State Hospital grounds. The environment in Cottage 13 was constructed so that it emitted a positive and optimistic atmosphere to ensure that the patients did not have a negative experience while taking the LSD treatment.
Even the sounds, smells, and objects in Cottage 13 were carefully conditioned. Before treatment, the patients were screened after mental breakdowns to determine if they were eligible for LSD treatment. Then they were given a microscopic dose of LSD in Cottage 13. During the 14-hour treatment, the patients underwent psychotherapy so that psychiatrists could attempt to identify underlying conflicts. In addition to the psychotherapy, patients also underwent psychiatric tests so that researchers could determine other effects of LSD, such as changes in IQ scores.
Those who observed the experiments in Cottage 13 encouraged the continuation of it. One such individual was Dr. John Buckman, who claimed that "the treatment procedure seemed to be returning the patients to the human race."
The results show that no patients were harmed. After six months, 33% of patients remained abstinent after LSD treatment, as opposed to the previous statistic of 12% under conventional therapy.
In 1965, the
Columbia Broadcasting System
CBS Broadcasting Inc., commonly shortened to CBS, the abbreviation of its former legal name Columbia Broadcasting System, is an American commercial broadcast television and radio network serving as the flagship property of the CBS Entertainmen ...
(CBS) television network produced a documentary called "LSD: The Spring Grove Experiment." LSD experimentation on the patients of Spring Grove became a part of the growing conversation on drugs.
The success of this documentary led to an insurgence of federal funding that would go into building a new research center in 1969, called the Maryland Psychiatric Research Center.
Expansion
The success of the trials resulted in an expansion of the treatment to other neurological diseases. The studies expanded to include neurotics and heroin addicts.
In 1966, experiments expanded to treat those with terminal cancers.
This type of experimentation arose at the Spring Grove clinic after one of the researchers became a human subject in the same clinic where she worked. Gloria
underwent the
radical mastectomy
Radical mastectomy is a surgical procedure involving the removal of breast, underlying chest muscle (including pectoralis major and pectoralis minor), and lymph nodes of the axilla as a treatment for breast cancer. Breast cancer is the most comm ...
procedure
to treat her breast cancer, and was subsequently diagnosed with liver cancer. Her resulting depression and anxiety were analogous to psychiatric symptoms, similar to those expressed by patients in the Spring Grove Clinic. After noticing the apparent effectiveness of LSD therapy on alcoholics, Gloria requested that an LSD treatment session be administered on herself. There had been existing studies on the chemotherapeutic
analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
effects of LSD, and the potential of LSD in alleviating the anguish of the dying. These most likely contributed to the permission Gloria received which allowed for the procedure. After consent was acquired, Gloria underwent psychedelic LSD therapy. She was administered a 200 microgram LSD session, and experienced successful results. She stated, "I am still me, but more at peace. My family senses this and we are closer. All who know me well say that this has been a good experience."
Gloria died five weeks later.
The staff at Spring Grove noticed the potential of LSD in treatment and began treating terminally-ill cancer patients to relieve suffering in the time leading up to death. A research study was developed under Dr. Walter N Pahnke, a graduate from Harvard Medicine with a degree in religion and divinity, and Dr. Eric Kast.
The thought was that LSD could serve as a narcotic and relieve the pain and suffering caused by cancer. In 1972, the study published a paper concluding that LSD had relieved pain in the terminally ill patients.
Thirty one terminally ill patients were treated and statistical results showed that patients received considerable relief from pain. However, flaws in the study invalidated the results including the different psychedelics used an unsystematic study design.
From 1969 to 1972, a variety of experiments were conducted as LSD's effects on mental health, and heroin addiction were examined. By 1976 the research at Spring Grove, which at that time had been rebuilt and renamed the Maryland Psychiatric Research Psychedelic Clinic, had come to an end.
Psychedelic psychotherapy
LSD was intravenously injected into patients, and at times was delivered through the form of a pill.
In the early experiments, LSD was administered in a single large dose along with a specialized environment, eyeshades, headphones, and selected music.
A preparatory period allowed a trained therapist to deeply explore the background of the patient. Doses ranged from 250 to 800 micrograms sessions, which would last from 8–12 hours.
This method was called the "mind-manifesting approach."
By the late 1970s, a more extensive method was developed, called "the extended paradigm," as named by Stanislav Grof. This involved the administration of several high doses, an increased number of therapeutic sessions, and a greater emphasis on personal dynamics between therapist and patient.
It was not expected that positive results would occur with pure drug administration. Psychedelic therapy involves the use of a hallucinogenic, perception-altering drugs coupled with psychotherapy to treat patients psychologically. The goal of the procedure was to unearth internal conflicts by administering LSD and then use therapy to resolve and work through these emerging latent conflicts. "Mystical peaks" experienced by LSD-treated patients would often give the patient insights and new outlooks on life. Therapy would be used to apply these insights to the individual's personal life.
Musical therapists eventually joined staffing. The main objective of therapy was to provide support and companionship to the patient.
Patients' experiences
In the original 1955 experiment conducted on patients with schizophrenia, there were 20 subjects that received LSD. The experiences and reactions of these subjects were categorized under 3 characteristics
covert, which signified a subtle or delayed response; intensification, which pushed the patient's existing symptoms to extremes; and reversal, which occurred when patients assumed a state opposite to his or her original symptoms.
The following are accounts of patient responses during several experiments conducted at Spring Grove:
In the 1955 trials on people with chronic schizophrenia:A second patient in the 1955 study who was normally aloof, laughing, and idle became uncharacteristically serious 30 minutes after drug administration. She called the doctor by his correct name for the first time, saying:In the 1965 CBS documentary, the story of Arthur King, a man experiencing alcoholism and being treated with LSD and psychotherapy, was highlighted.
Some of the alcoholic patients who underwent LSD and psychotherapy treatment at Spring Grove felt happier after the treatment and had no more desire to drink. One patient, Arthur King, was admitted into Spring Grove State Hospital as an alcoholic. He underwent the treatment. Afterwards, he reported that he had no more desire to drink—he went back to school and later became an accountant. Years later when he was interviewed, he said that the LSD treatment turned his life around.
In an interview conducted by Richard Yensen, Arthur King stated the following concerning treatment: The peak experience was defined by the following guidelines
Shortcomings
The first shortcoming determined early on in experimentation was that no adequate
control group
In the design of experiments, hypotheses are applied to experimental units in a treatment group.
In comparative experiments, members of a control group receive a standard treatment, a placebo, or no treatment at all. There may be more than one tr ...
could be defined. This occludes the value of the results, and makes it difficult to deduce whether findings in the experiment were due LSD administration or simply just results of intense therapy following the drug administration. Another issue was the inability to conduct the experiment utilizing the blind double-blind procedure. An additional strong criticism of the experiments was that non-drug effects on the subjects were largely underestimated, and the effects of the LSD were possibly overestimated.
Although the overall outcome of the treatment in the Spring Grove Experiments was generally positive, there were also negative effects of LSD treatment in the patient including intense fear, uncontrollable breakdowns, and emotional stress during treatment. LSD was also known to produce feelings of depression, headache, and depersonalization in some cases.
In addition, since subjects received LSD treatment and psychotherapy treatment, it is unclear whether the LSD caused the positive outcomes, the psychotherapy, or the carefully prepared combination of LSD and psychotherapy treatment.
These shortcomings demonstrate the possibility that beneficial results in the experiments may not be attributed solely to LSD treatment. Rather, it may be more likely that results occurred out of combination of the effects of social setting, therapy, and drug administration.
Controversy and resistance
Resistance from the scientific community to psychedelic therapy is thought to have resulted from certain restrictive paradigms about how studies in psychiatry and psychology should be carried out, and which ones are valid. The existing concept supported single solutions to mental health issues, and prescribing pharmaceutical drugs to biologically suppress symptoms of diseases rather than root causes. This focus on pharmaceuticals existed partially because the large amounts of government funding given to pharmaceutical companies.
Controversy on the use of psychedelics as medical treatment was particularly significant considering this time period (1970) constituted the early stages of the declared "
war on drugs
The war on drugs is a Globalization, global campaign, led by the United States federal government, of prohibition of drugs, drug prohibition, military aid, and military intervention, with the aim of reducing the illegal drug trade in the Unite ...
." This, along with sensationalized negative LSD cases disseminated by the media, led to a declined attitude toward the usage of LSD as treatment. Other factors such as the accusation that scientists were mismanaging money, and the concern of LSD causing chromosome damage in 1969 led to further negative attitudes toward the study.
Termination
The studies at Spring Grove State Hospital ended in 1976.
Several factors led to the termination of the Spring Grove Experiment.
In 1971 Walter Pahnke, the director of clinical science and leader of the Spring Grove research team at the time, died.
His successor had no background in psychedelic research and therefore did not have the experience or drive to continue the experimentation being led by Pahnke before he died. The Maryland Psychiatric Research Center was accused of improper use of public money and not engaging in real treatment that would be beneficial to the public.
When legislation was passed resulting in the detraction of funding from state hospitals, animosity grew between the more privileged researchers and the hospital employees. This discouraged workers from getting involved in experiments, adding to the growing negative atmosphere around LSD research. In addition, controversy surrounding the use of LSD in experiments surfaced. Among these controversies include reports of a suicide in
Project MKUltra
Project MKUltra (or MK-Ultra) was an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA), intended to develop procedures and identify drugs that could be used in interrogations to weak ...
and treatment with LSD without informed consent at
Edgewood Arsenal
Aberdeen Proving Ground (APG) (sometimes erroneously called Aberdeen Proving ''Grounds'') is a U.S. Army facility located adjacent to Aberdeen, Harford County, Maryland, United States. More than 7,500 civilians and 5,000 military personnel work a ...
in the late 1970s. Because the arsenal had ties to the University of Maryland, there was dramatic pressure to discontinue all research involving psychedelics as treatment. The accumulation of these reports, along with general reservations about medicalizing what the media portrayed as strictly deleterious, led to the termination of the psychedelic experiments on human subjects at Spring Grove.
Legacy
By 1976, more than 700 patients were treated with psychedelic drugs. This produced positive yet equivocal results. Most benefitted, and a minority did not display any response, however, there is no awareness of long-term complications.
By the 1970s, LSD was no longer recognized as having a medical use. It was instead seen as having a great potential for abuse and addiction. In the 1990s, even when Dr. Yensen and Dr. Kurland received
FDA
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...
approval to continue LSD research, they were unable to acquire the LSD for clinical study in the United States.
Today, LSD research is gradually re-emerging as a focus for clinical researchers. In 2014, there was a study on the effects of LSD and psychotherapy on patients experiencing anxiety. In 2013, studies were being done on patients experiencing
Post Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a mental and behavioral disorder that can develop because of exposure to a traumatic event, such as sexual assault, warfare, traffic collisions, child abuse, domestic violence, or other threats on a ...
combining
MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in Tablet (pharmacy), tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for Recreational dru ...
and psychotherapy; and in 2016, an article was released announcing the FDA's approval of clinical studies supporting further experiments to devise a drug for treatment of PTSD.
Dr. Kurland's initial hopes to produce "effective therapies that will heal – more quickly and comfortably – the psychic wounds that leave so many people handicapped and alienated" remain.
References
{{reflist, 30em
Mental health in the United States
Lysergic acid diethylamide