The spiroindolones are a class of compounds in which an
indolone ring is substituted with another ring in a
spiro arrangement.
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...
s in this class include
horsfiline,
rhynchophylline
Rhynchophylline is an alkaloid found in certain ''Uncaria'' species (Rubiaceae), notably '' Uncaria rhynchophylla'' and '' Uncaria tomentosa''. It also occurs in the leaves of ''Mitragyna speciosa'' (kratom), a tree native to Thailand. Chemicall ...
,
gelsemine
Gelsemine (C20H22N2O2) is an indole alkaloid isolated from flowering plants of the genus ''Gelsemium'', a plant native to the subtropical and tropical Americas, and southeast Asia, and is a highly toxic compound that acts as a paralytic, exposu ...
,
carapanaubine, and
maremycin E.
Spiroindolones are also an emerging class of
antimalarial drug
Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young c ...
s
whose mode of action is to inhibit protein synthesis in the target parasite. The most advanced compound in this class in terms of
drug development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for re ...
is
cipargamin (NITD609).
References
Antimalarial agents
Spiro compounds
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