"Spin" is the sixth episode of the second season of ''

House A house is a single-unit residential building. It may range in complexity from a rudimentary hut to a complex structure of wood, masonry, concrete or other material, outfitted with plumbing, electrical, and heating, ventilation, and air condi ...

'', which premiered on

Fox Foxes are small to medium-sized, omnivorous mammals belonging to several genera of the family Canidae. They have a flattened skull, upright, triangular ears, a pointed, slightly upturned snout, and a long bushy tail (or ''brush''). Twelve sp ...

on November 15, 2005.

Summary

Jeff, a well-known cyclist, is cycling in a non-profit charity race, when he is unable to breathe and taken to the hospital. House finds it surprising that Jeff admitted he is taking illegal enhancement drugs. He agreed to blood doping, which is common among cyclists, to better one's athletic performance. Because red blood cells carry oxygen between the lungs and the muscles, a higher number of red blood cells can increase an athlete's endurance. While trying to figure out what cause of Jeff's respiratory distress, they find an air embolus in his chest. While Dr. Chase works to remove the air bubble, Jeff begins to feel numbness in his legs, but is told that it might be due to the sedation. While his manager talks to the press, Jeff loses feeling in his legs. Dr. Cameron informs House that Jeff's red blood count is continually dropping, revealing that his body is no longer able to produce red blood cells on its own. House becomes convinced that Jeff lied about a specific drug that could be the cause of all of his symptoms,

erythropoietin Erythropoietin (; EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bo ...

(EPO), a hormone produced in the kidney that promotes the formation of red blood cells by the bone marrow. Adding more red blood cells increases the oxygen level in the blood, thus presumably causing all of Jeff's symptoms as he fails to produce red blood cells on his own. This explains him also having anemia, caused by chronic Acquired Pure Red Cell Aplasia (PRCA), probably resulting from blood doping. After responding to

prednisone Prednisone is a glucocorticoid medication mostly used to immunosuppressive drug, suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium ...

, Jeff begins losing more red blood cells, to the point of requiring a transfusion. House scans Jeff's neck and a

thymoma A thymoma is a tumor originating from the epithelial cells of the thymus that is considered a rare malignancy. Thymomas are frequently associated with neuromuscular disorders such as myasthenia gravis; thymoma is found in 20% of patients with mya ...

is discovered; an extremely rare tumor on the

thymus The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, thymus cell lymphocytes or ''T cells'' mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders. ...

, confirming that he wasn't taking EPO, but did have Chronic Acquired Pure Red Cell Aplasia. Due to the diagnosis he can legally blood dope or get a thymectomy, which could only bring a temporary remission, after which he would have to be on medical steroids.

External links

"Spin"
at

Fox.com The Fox Broadcasting Company, commonly known simply as Fox and stylized in all caps as FOX, is an American commercial broadcast television network owned by Fox Corporation and headquartered in New York City, with master control operations and ...

* {{House (TV series) House (season 2) episodes 2005 American television episodes fr:La Course au mensonge