The Spi-1 (PU.1) 5′ UTR regulatory element is an
RNA element found in the
5′ UTR
The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of ...
of Spi-1
mRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein.
mRNA is ...
which is able to inhibit the
translation
Translation is the communication of the Meaning (linguistic), meaning of a #Source and target languages, source-language text by means of an Dynamic and formal equivalence, equivalent #Source and target languages, target-language text. The ...
Spi-1 transcripts by 8-fold.
Spi-1 regulates myeloid gene expression during
haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of
Spi-1 which has been linked to development of
leukaemia
Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...
.
See also
*
InvR
References
External links
*
Cis-regulatory RNA elements
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