Sisto can refer to:
*
San Sisto, "Saint Sixtus", dedication of several Italian churches
*
Sisto, character on ''The Brak Show''
*
Jeremy Sisto, American actor
*
José Sisto, Spanish politician, Governor of Guam
*
Meadow Sisto, American actress
*
Pione Sisto, Ugandan-born Danish footballer of South Sudanese origin
*
Rocco Sisto, Italian actor
*Sister Sisto, a character from the animated series
Solar Opposites
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