Sir Thomas Lewis
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Sir Thomas Lewis,
CBE The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established o ...
, FRS, FRCP (26 December 1881 – 17 March 1945) was a British
cardiologist Cardiology () is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular hear ...
(although he personally disliked the term, preferring
cardiovascular disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, h ...
specialist). He coined the term "
clinical science Clinical research is a branch of healthcare science that determines the safety and effectiveness ( efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatm ...
".Biography, ''
Oxford Dictionary of National Biography The ''Dictionary of National Biography'' (''DNB'') is a standard work of reference on notable figures from British history, published since 1885. The updated ''Oxford Dictionary of National Biography'' (''ODNB'') was published on 23 September ...
''


Early life and education

Lewis was born in
Taffs Well Taff's Well () is a semi-rural village, community and electoral ward located at the south easterly tip of Rhondda Cynon Taf, to the north of Cardiff, the capital city of Wales. Known locally as the 'Gates to the Valleys', it is separated from Gwa ...
,
Cardiff Cardiff (; cy, Caerdydd ) is the capital and largest city of Wales. It forms a principal area, officially known as the City and County of Cardiff ( cy, Dinas a Sir Caerdydd, links=no), and the city is the eleventh-largest in the United Kingd ...
,
Wales Wales ( cy, Cymru ) is a Countries of the United Kingdom, country that is part of the United Kingdom. It is bordered by England to the Wales–England border, east, the Irish Sea to the north and west, the Celtic Sea to the south west and the ...
, the son of Henry Lewis, a mining engineer, and his wife Catherine Hannah (née Davies). He was educated at home by his mother, apart from a year at
Clifton College ''The spirit nourishes within'' , established = 160 years ago , closed = , type = Public schoolIndependent boarding and day school , religion = Christian , president = , head_label = Head of College , head ...
, which he left due to ill-health, and the final two years by a tutor. Already planning to become a doctor, at the age of sixteen he began a
Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University of ...
(BSc) course at
University College, Cardiff , latin_name = , image_name = Shield of the University of Cardiff.svg , image_size = 150px , caption = Coat of arms of Cardiff University , motto = cy, Gwirionedd, Undod a Chytgord , mottoeng = Truth, Unity and Concord , established = 1 ...
, graduating three years later with first class honours. In 1902 he entered
University College Hospital University College Hospital (UCH) is a teaching hospital in the Fitzrovia area of the London Borough of Camden, England. The hospital, which was founded as the North London Hospital in 1834, is closely associated with University College London ...
in
London London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...
to train as a doctor, graduating
MBBS Bachelor of Medicine, Bachelor of Surgery ( la, Medicinae Baccalaureus, Baccalaureus Chirurgiae; abbreviated most commonly MBBS), is the primary medical degree awarded by medical schools in countries that follow the tradition of the United King ...
with the gold medal in 1905. The same year he was awarded a
Doctor of Science Doctor of Science ( la, links=no, Scientiae Doctor), usually abbreviated Sc.D., D.Sc., S.D., or D.S., is an academic research degree awarded in a number of countries throughout the world. In some countries, "Doctor of Science" is the degree used f ...
(DSc) degree from the
University of Wales The University of Wales (Welsh language, Welsh: ''Prifysgol Cymru'') is a confederal university based in Cardiff, Wales. Founded by royal charter in 1893 as a federal university with three constituent colleges – Aberystwyth, Bangor and Cardiff †...
for his research work.


Career

He remained at UCH for the rest of his life, beginning as a house physician. From 1907 he also worked at the
Royal Naval Hospital, Greenwich Greenwich Hospital was a permanent home for retired sailors of the Royal Navy, which operated from 1692 to 1869. Its buildings, in Greenwich, London, were later used by the Royal Naval College, Greenwich and the University of Greenwich, and ar ...
and the City of London Hospital and the same year he took his
Doctor of Medicine Doctor of Medicine (abbreviated M.D., from the Latin language, Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a profes ...
(MD) degree. In 1911 he was appointed lecturer in cardiac
pathology Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in ...
at UCH and in 1913 was promoted to assistant physician in clinical work. He was elected
Fellow of the Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...
(FRCP) in 1913. While still a house physician, Lewis began
physiological Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...
research, carrying out fundamental research on the heart, the
pulse In medicine, a pulse represents the tactile arterial palpation of the cardiac cycle (heartbeat) by trained fingertips. The pulse may be palpated in any place that allows an artery to be compressed near the surface of the body, such as at the nec ...
and
blood pressure Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" r ...
. From 1906, he corresponded with the Dutch physiologist
Willem Einthoven Willem Einthoven (21 May 1860 – 29 September 1927) was a Dutch doctor and physiologist. He invented the first practical electrocardiograph (ECG or EKG) in 1895 and received the Nobel Prize in Physiology or Medicine in 1924 for it ("for the dis ...
concerning the latter's invention of the string galvanometer and
electrocardiography Electrocardiography is the process of producing an electrocardiogram (ECG or EKG), a recording of the heart's electrical activity. It is an electrogram of the heart which is a graph of voltage versus time of the electrical activity of the hear ...
, and Lewis pioneered its use in clinical settings. Accordingly, Lewis is considered the "father of clinical cardiac electrophysiology". The first use of electrocardiography in clinical medicine was in 1908. In that year, Thomas Lewis and
Arthur MacNalty Sir Arthur Salusbury MacNalty (20 October 1880 – 11 April 1969) was the 8th Chief Medical Officer (United Kingdom), Chief Medical Officer of the United Kingdom. Arthur MacNalty was also a ground breaking medical scientist. In 1908, early in his ...
(later the Chief Medical Officer of the United Kingdom) employed electrocardiography to diagnose
heart block Heart block (HB) is a disorder in the heart's rhythm due to a fault in the natural pacemaker. This is caused by an obstruction – a block – in the electrical conduction system of the heart. Sometimes a disorder can be inherited. Despite the se ...
. In 1909, with James MacKenzie, Lewis founded the journal ''Heart: A Journal for the Study of the Circulation'', which he renamed ''
Clinical Science Clinical research is a branch of healthcare science that determines the safety and effectiveness ( efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatm ...
'' in 1933. In 1913, he published the book ''Clinical Electrocardiography'', the first treaty on electrocardiography. Lewis was elected a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
(FRS) in 1918. He was promoted to full physician at UCH in 1919. During the
First World War World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...
, Lewis worked at the
Military Heart Hospital A military, also known collectively as armed forces, is a heavily armed, highly organized force primarily intended for warfare. It is typically authorized and maintained by a sovereign state, with its members identifiable by their distinct ...
in
Hampstead Hampstead () is an area in London, which lies northwest of Charing Cross, and extends from Watling Street, the A5 road (Roman Watling Street) to Hampstead Heath, a large, hilly expanse of parkland. The area forms the northwest part of the Lon ...
and was appointed to the first full-time clinical research post in Britain, at the Medical Research Committee (later Medical Research Council). He directed a study of the condition known as "soldier's heart" and, having established it was not a cardiological problem, renamed it the "
effort syndrome Da Costa's syndrome (also known as "soldier's heart", cardiac neurosis, chronic asthenia, effort syndrome, functional cardiovascular disease, neurocirculatory asthenia, primary neurasthenia, subacute asthenia and irritable heart) is a psychiatr ...
". In 1918 he wrote the monograph ''The Soldier's Heart and the Effort Syndrome''. He devised remedial exercises that allowed many soldiers suffering from the condition to return to duty and was appointed honorary consulting physician to the
Ministry of Pensions Ministry may refer to: Government * Ministry (collective executive), the complete body of government ministers under the leadership of a prime minister * Ministry (government department), a department of a government Religion * Christian ...
in April 1919, and for this work he was appointed
Commander of the Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established o ...
(CBE) in January 1920 and was
knighted A knight is a person granted an honorary title of knighthood by a head of state (including the Pope) or representative for service to the monarch, the Christian denomination, church or the country, especially in a military capacity. Knighthood ...
in the
1921 Birthday Honours The 1921 Birthday Honours were appointments by King George V to various orders and honours to reward and highlight good works by citizens of the British Empire. The appointments were made to celebrate the official birthday of the King, and were ...
. After the war, he established the clinical research department at UCH and continued his work on
cardiac arrhythmia Arrhythmias, also known as cardiac arrhythmias, heart arrhythmias, or dysrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow. A resting heart rate that is too fast – above 100 beats per minute in adults ...
. In 1925 he switched his focus from cardiography to vascular reactions of the skin. In 1917 he had shown that
capillaries A capillary is a small blood vessel from 5 to 10 micrometres (μm) in diameter. Capillaries are composed of only the tunica intima, consisting of a thin wall of simple squamous endothelial cells. They are the smallest blood vessels in the body: ...
had independent contractions and he now investigated the response of the skin to injury, leading to the 1927 monograph ''The Blood Vessels of the Human Skin and their Responses''. He was awarded the
Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
's
Royal Medal The Royal Medal, also known as The Queen's Medal and The King's Medal (depending on the gender of the monarch at the time of the award), is a silver-gilt medal, of which three are awarded each year by the Royal Society, two for "the most important ...
in 1927 "for his researches on the vascular system, following upon his earlier work on the mammalian heart-beat." Next, he switched his focus to
peripheral vascular disease Peripheral artery disease (PAD) is an abnormal narrowing of arteries other than those that supply the heart or brain. When narrowing occurs in the heart, it is called coronary artery disease, and in the brain, it is called cerebrovascular diseas ...
, especially
Raynaud's disease Raynaud syndrome, also known as Raynaud's phenomenon, eponymously named after the physician Auguste Gabriel Maurice Raynaud, who first described it in his doctoral thesis in 1862, is a medical condition in which the spasm of small arteries cau ...
, and finally to the mechanism of pain, summarising his findings in ''Pain'' in 1942. His 1932 book ''Diseases of the Heart'' became a standard medical text. In 1930 he described the
Hunting reaction The hunting reaction or hunting response is a process of alternating vasoconstriction and vasodilation in extremities exposed to cold. The term Lewis reaction is used too, named after Thomas Lewis, who first described the effect in 1930. Vasocons ...
, alternating vasodilation and vasoconstriction of peripheral capillaries in cold environments. In 1930, he founded the Medical Research Society. He was awarded the Royal Society's
Copley Medal The Copley Medal is an award given by the Royal Society, for "outstanding achievements in research in any branch of science". It alternates between the physical sciences or mathematics and the biological sciences. Given every year, the medal is t ...
in 1941 "for his clinical and experimental investigations upon the mammalian heart." He was only the second clinician to receive it, after
Lord Lister Joseph Lister, 1st Baron Lister, (5 April 182710 February 1912) was a British surgeon, medical scientist, experimental pathologist and a pioneer of antiseptic surgery and preventative medicine. Joseph Lister revolutionised the craft of su ...
in 1902. He served as vice-president of the Royal Society from 1943 to 1945. Lewis suffered a
myocardial infarction A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may ...
at the age of 45 and gave up his 70-cigarette-a-day habit, being one of the first to realise that smoking damaged the blood vessels. He died from
coronary heart disease Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or simply heart disease, involves the reduction of blood flow to the heart muscle due to build-up of atherosclerotic pla ...
at his home at
Loudwater, Hertfordshire Loudwater is a private housing estate in the parish of Chorleywood, separated from the latter by the River Chess, north of Rickmansworth, Hertfordshire and just to the east of Junction 18 of the M25 motorway. Loudwater is an old name for the River ...
on 17 March 1945, at age 63.


Family

He married Alice Lorna Treharne James in 1916. They had three children.


Publications

*''The Mechanism of the Heart Beat'' (1911) *''Clinical Electro-Cardiography'' (1913)


References

{{DEFAULTSORT:Lewis, Thomas 1881 births 1945 deaths People from Taff's Well Medical doctors from Cardiff People educated at Clifton College Alumni of Cardiff University Alumni of the UCL Medical School 20th-century Welsh medical doctors British cardiologists British physiologists Commanders of the Order of the British Empire Knights Bachelor Fellows of the Royal Society Fellows of the Royal College of Physicians Recipients of the Copley Medal Royal Medal winners