A Signal-regulatory protein (SIRP) is one of a family of
transmembrane glycoprotein
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycos ...
s involved in immunological signalling, expressed mainly by
myeloid cell
A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow (can be found in circulating blood when caused by certain diseases).
Structure
When stained with the usual dyes, the cytoplasm is distinctly basophilic ...
s.
Members include :
*
Signal-regulatory protein alpha
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.
SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembra ...
,
ligand=
CD47[
* ]SIRPB1
Signal-regulatory protein beta-1 is a protein that in humans is encoded by the ''SIRPB1'' gene. SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).
The protein encoded by this gene is a member of the signal-regulator ...
* SIRPB2SIRPG
Signal-regulatory protein gamma is a protein that in humans is encoded by the ''SIRPG'' gene. SIRPG has also recently been designated CD172G (cluster of differentiation 172G).
The protein encoded by this gene is a member of the signal-regulatory ...
, ligand=CD47[
]
References
Single-pass transmembrane proteins
{{membrane-protein-stub