Signal peptidase II

Signal peptidase II (, ''premurein-leader peptidase'', ''prolipoprotein signal peptidase'', ''leader peptidase II'', ''premurein leader proteinase'') is an enzyme.

This enzyme catalyses a chemical reaction. It releases signal peptides from murein prolipoprotein and other bacterial membrane prolipoproteins. It also hydrolyses -Xaa-Yaa-Zaa-(S,diacylglyceryl)Cys-, in which Yaa (Ala or Ser) and Zaa (Gly or Ala) have small neutral sidechains, and Xaa is hydrophobic (preferably Leu).

This enzyme is present in bacterial inner membranes.

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EC 3.4.23