Shahinaz Mohamed Aly Gadalla is a physician-scientist and cancer epidemiologist who researches

cancer biomarker A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer. Genetic, epigenetic, pr ...

s and hematopoietic stem cell transplantation. She is a senior investigator in the clinical genetics branch at the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

Life

Shahinaz Mohamed Aly Gadalla was born to Mohamed and Sabah. She earned a M.B.Bch from Ain Shams University Faculty of Medicine In 1996. She completed a medical internship in 1998 at Ain Shams University Hospitals. Gadallah completed a M.S. (2005) in epidemiology and

preventative medicine Preventive healthcare, or prophylaxis, consists of measures taken for the purposes of disease prevention.Hugh R. Leavell and E. Gurney Clark as "the science and art of preventing disease, prolonging life, and promoting physical and mental hea ...

and a Ph.D. (2008) in epidemiology from the University of Maryland, Baltimore. Her dissertation was titled, ''Systemic autoimmune rheumatic diseases and breast cancer risk in elderly women''. Sania Amr was her doctoral advisor. Gadalla dedicated her dissertation to her daughter. She joined the clinical genetics branch (CGB) within the

(NCI) division of cancer epidemiology and genetics as a cancer prevention fellow in 2008. Gadalla was promoted to a staff scientist in 2011 and was appointed as an Earl Stadtman Tenure-Track Investigator in 2014. She was awarded

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

(NIH) scientific tenure and appointed senior investigator in 2022. Gadalla's research interests focus on identifying and characterizing individuals at high risk of developing cancer and discovering predictive and prognostic biomarkers that may guide therapeutic decisions for those patients. In 2011, Gadalla and colleagues were the first to report epidemiological evidence of excess cancer risk in

myotonic dystrophy Myotonic dystrophy (DM) is a type of muscular dystrophy, a group of genetic disorders that cause progressive muscle loss and weakness. In DM, muscles are often unable to relax after contraction. Other manifestations may include cataracts, intel ...

(DM) patients. She also researches molecular predictors of outcomes after hematopoietic cell transplantation. Gadalla's work focuses on severe aplastic anemia and myeloid neoplasms with a goal of identifying biomarkers that can guide donor selection or patient risk stratification. Her investigations include markers of cellular aging, germline genetic variants, and somatic copy-number alterations.

References

{{DEFAULTSORT:Gadalla, Shahinaz Living people Year of birth missing (living people) Place of birth missing (living people) Ain Shams University alumni University of Maryland, Baltimore alumni 21st-century American women physicians 21st-century American physicians 21st-century Egyptian women 21st-century Egyptian people Egyptian women physicians National Institutes of Health people Egyptian emigrants to the United States Physician-scientists Cancer epidemiologists American women epidemiologists American epidemiologists