Education and training
In 1985, Keshavjee completed his medical degree at the University of Toronto. He did a comprehensive surgical internship at the Mount Sinai Hospital in 1986. His Research Fellowship and Surgical Scientist Program in the Division of Thoracic Surgery were done at the University of Toronto and Toronto General Hospital in 1989. That same year he received his MSc in the Institute of Medical Science at theCurrent appointments
* 1994–Present: Director of Thoracic Surgery Research Laboratory, Toronto General Research Institute (TGRI) and University of Toronto (U of T) * 1995–Present: Faculty in the Institute of Medical Sciences, School of Graduate Studies at the University of Toronto * 1997–Present: Senior Scientist, Division of Experimental Therapeutics, UHN, TGRI * 1997–Present: Director, Toronto Lung Transplant Program,Awards and recognition
Boards and societies
Dr. Keshavjee has served on the board of directors of the International Society for Heart and Lung Transplantation, the Canadian Society of Transplantation, and on the Governing Council of the American Association for Thoracic Surgery.Awards
Over the course of his career, he has received many awards for his medical contributions. These have included: * The George Armstrong Peters Young Investigator Award * Canada's Top 40 Under 40 Award * The Colin Woolf Award for Excellence in Continuing Medical Education * The Lister Prize inTED MED
At TED MED 2010, Dr. Keshavjee gave a talk entitled ‘Can a human lung breathe outside the body in which he addressed the process of repairing organs outside the human body.Achievements
At his Thoracic Surgery Research Laboratory, Dr. Kehavjee's research interests include lung transplantation, lung injury, and lung preservation. His current studies examine molecular diagnostics and gene therapy strategies for engineering organs for lung transplantation. The Lab's work explores the underlying mechanisms of ischemia-reperfusion injury and bronchiolitis obliterans – two areas that limit successful lung transplantation – and develops gene therapy strategies for either preventing or reversing them. Several areas within ischemia-reperfusion injury are examined, including the role of complement and cytokine-related lung injury and its relation to reperfusion. The work is done onLung preservation
Keshavjee and his research team have developed a technique of lung preservation that can improve lung function after its transplantation. The solution is made from low-potassium dextran and is used in the Ex Vivo. The LPD solution is applied in both the Toronto lung transplant program and in clinical programs around the world.Gene therapy in lung transplantation
Keshavjee's research team focuses its main efforts on the role of gene therapy in lung transplantation. They are currently developing techniques for genetically modifying the donor lung so it can withstand stress during the transplant process. Ultimately, these techniques would be used to address both ischemia-reperfusion injury and obliterative bronchiolitis. Keshavjee's work has demonstrated that immunosuppression related to transplantation leads to an altered expression of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene. To this effect, he and his team have proved that gene therapy will help recipients recover from lung transplantation surgery without a significant immune system response. When addressing obliterative bronchiolitis in a rat tracheal transplant model of fibrous airway obliteration related to transplantation, Dr. Keshavjee's research showed that the adenoviral IL-10 gene transfection was able to prevent the development of bronchiolitis obliterans. This was the first time that a gene therapy strategy was able to treat this condition; a significant breakthrough as this condition affects over 50% of lung transplant recipients. The team is currently studying the effect of the IL-10 transfection on ischemia-reperfusion therapy, as well as mechanisms of cell death and the genes controlling the process.Toronto Lung Transplant Program
Keshavjee currently serves as the Director of the Toronto Lung Transplant Program, a University of Toronto program that spans across UHN and the Hospital for Sick Children. It began in 1983, and expanded to pediatric lung transplantation surgeries in 1995. Located in the Toronto General Hospital, it has gained international recognition for performing several remarkable firsts, including: First successful single-lung transplant, first successful double lung transplant, first pediatric lung transplant, first pediatric lung transplant with mismatched blood types, first to use an EXVIVO outside of the body, and the first to use the Novalung ventilator to provide more time for those awaiting transplantation. The TLTP uses 40% of the donated lungs it receives, compared to 15% of donated lungs used elsewhere in the world. As a result of Keshavjee's breakthroughs, there have been steady increases in the number of transplants and the survival rate. While the one-year survival rate for lung transplant recipients is 85% and almost 30% for over 10 years, the TLTP has 22 patients who have survived 20 or more years after receiving their donor lungs. A gene-therapy trial will begin next year.Toronto Ex Vivo Lung Perfusion System (EVLP)
Keshavjee was internationally recognized for his leadership in the development of the Toronto Ex Vivo Lung Perfusion System, which treats and improves high-risk donor lungs outside of a human body so that they can be safely used for transplantation. Donor lungs are placed in ice, with one tube attached to the pulmonary artery and another sewn to a vein used for training blood out of the lung. The lung is then moved onto a steel platform atop the device and hooked to a circuit with a ventilator and heart-lung mimicking machine that pumps the preservation solution into them. As they are brought up to body temperature, they are healed with an anti-inflammatory solution (developed by Dr. Keshavjee). Eventually, the lungs begin to inflate and deflate as they breathe on their own. For several hours, the lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to the flow of fluid, and whether they are becoming less stiff. If the tests are deemed successful for function, they may go ahead and perform the transplantation.References
{{DEFAULTSORT:Keshavjee, Shaf Living people Canadian transplant surgeons Canadian Ismailis Kenyan Ismailis Members of the Order of Ontario Officers of the Order of Canada Physicians from Toronto Academic staff of the University of Toronto Year of birth missing (living people) Presidents of the American Association for Thoracic Surgery