Seymour Benzer (October 15, 1921 – November 30, 2007) was an American

physicist A physicist is a scientist who specializes in the field of physics, which encompasses the interactions of matter and energy at all length and time scales in the physical universe. Physicists generally are interested in the root or ultimate caus ...

molecular biologist Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

and behavioral geneticist. His career began during the molecular biology revolution of the 1950s, and he eventually rose to prominence in the fields of molecular and behavioral genetics. He led a productive genetics research lab both at Purdue University and as the James G. Boswell Professor of Neuroscience, Emeritus, at the

California Institute of Technology The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...

Biography

Early life and education

Benzer was born in the

South Bronx The South Bronx is an area of the New York City Borough (New York City), borough of the Bronx. The area comprises neighborhoods in the southern part of the Bronx, such as Concourse, Bronx, Concourse, Mott Haven, Bronx, Mott Haven, Melrose, B ...

to Meir Benzer and Eva Naidorf, both Jews from Poland. He had two older sisters, and his parents favored him as the only boy. One of Benzer's earliest scientific experiences was dissecting frogs he had caught as a boy. In an interview at Caltech, Benzer also remembered receiving a microscope for his 13th birthday, “and that opened up the whole world.” The book '' Arrowsmith'' by

Sinclair Lewis Harry Sinclair Lewis (February 7, 1885 – January 10, 1951) was an American writer and playwright. In 1930, he became the first writer from the United States (and the first from the Americas) to receive the Nobel Prize in Literature, which was ...

heavily influenced the young Benzer, and he even imitated the handwriting of Max Gottlieb, a scientist character in the novel. Benzer graduated from

New Utrecht High School New Utrecht High School is a state school, public Secondary education in the United States, high school located in Bensonhurst, a neighborhood of Brooklyn, New York (state), New York. The school is operated by the New York City Department of Educat ...

at 15 years old. In 1938 he enrolled at

Brooklyn College Brooklyn College is a public university in Brooklyn, Brooklyn, New York. It is part of the City University of New York system and enrolls about 15,000 undergraduate and 2,800 graduate students on a 35-acre campus. Being New York City's first publ ...

where he majored in physics. Benzer then moved on to

Purdue University Purdue University is a public land-grant research university in West Lafayette, Indiana, and the flagship campus of the Purdue University system. The university was founded in 1869 after Lafayette businessman John Purdue donated land and money ...

to earn his Ph.D. in solid state physics. While there he was recruited for a secret military project to develop improved radar. He performed research that led to the development of stable

germanium Germanium is a chemical element with the symbol Ge and atomic number 32. It is lustrous, hard-brittle, grayish-white and similar in appearance to silicon. It is a metalloid in the carbon group that is chemically similar to its group neighbors s ...

rectifiers and discovered a germanium crystal able to be used at high voltages, among the scientific work that led to the first

transistor upright=1.4, gate (G), body (B), source (S) and drain (D) terminals. The gate is separated from the body by an insulating layer (pink). A transistor is a semiconductor device used to Electronic amplifier, amplify or electronic switch, switch e ...

Personal life

, as a sixteen-year-old freshman, Benzer met Dorothy Vlosky (nicknamed Dotty), a twenty-one-year-old nurse. He later married her in

New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...

in 1942. They had two daughters, Barbie (Barbara) and Martha Jane. Benzer died of a stroke at the

Huntington Hospital Huntington Memorial Hospital is a 619-bed not-for-profit hospital in Pasadena, California. The official name of the hospital is Pasadena Hospital DBA (doing business as) Huntington Memorial Hospital, known locally as HMH, Huntington Memorial or ...

Pasadena, California Pasadena ( ) is a city in Los Angeles County, California, northeast of downtown Los Angeles. It is the most populous city and the primary cultural center of the San Gabriel Valley. Old Pasadena is the city's original commercial district. I ...

Scientific career

Molecular biology

Upon receiving his Ph.D. in 1947, he was immediately hired as an assistant professor in physics at Purdue. However, Benzer was inspired by Erwin Schrödinger's book ''

What Is Life? ''What Is Life? The Physical Aspect of the Living Cell'' is a 1944 science book written for the lay reader by physicist Erwin Schrödinger. The book was based on a course of public lectures delivered by Schrödinger in February 1943, under the ...

'', in which the physicist pondered the physical nature of the gene and a “code” of life. This catalyzed Benzer's shift in interest to biology, and he moved into the area of

bacteriophage A bacteriophage (), also known informally as a ''phage'' (), is a duplodnaviria virus that infects and replicates within bacteria and archaea. The term was derived from "bacteria" and the Greek φαγεῖν ('), meaning "to devour". Bacteri ...

genetics., spending two years as a postdoctoral fellow in

Max Delbrück Max Ludwig Henning Delbrück (; September 4, 1906 – March 9, 1981) was a German–American biophysicist who participated in launching the molecular biology research program in the late 1930s. He stimulated physical science, physical scientist ...

's laboratory at California Institute of Technology, and then returning to Purdue. At Purdue University, Benzer developed the T4 ''rII'' system, a new genetic technique involving recombination in T4 bacteriophage ''rII'' mutants. After observing that a particular ''rII'' mutant, a mutation that caused the bacteriophage to eliminate bacteria more rapidly than usual, was not exhibiting the expected phenotype, it occurred to Benzer that this strain might have come from a cross between two different ''rII'' mutants (each having part of the ''rII'' gene intact) wherein a recombination event resulted in a normal ''rII'' sequence. Benzer realized that by generating many ''r'' mutants and recording the

recombination frequency Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Two genetic markers that are physically near to each other are unlikely to be separ ...

between different ''r'' strains, one could create a detailed map of the gene, much as

Alfred Sturtevant Alfred Henry Sturtevant (November 21, 1891 – April 5, 1970) was an American geneticist. Sturtevant constructed the first genetic map of a chromosome in 1911. Throughout his career he worked on the organism ''Drosophila melanogaster'' with ...

had done for

chromosomes A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...

. Taking advantage of the enormous number of recombinants that could be analyzed in the ''rII'' mutant system, Benzer was eventually able to map over 2400 ''rII'' mutations. The data he collected provided the first evidence that the gene is not an indivisible entity, as previously believed, and that genes were linear. Benzer also proved that

mutation In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mi ...

s were distributed in many different parts of a single gene, and the resolving power of his system allowed him to discern mutants that differ at the level of a single

nucleotide Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules wi ...

. Based on his ''rII'' data, Benzer also proposed distinct classes of mutations including deletions,

point mutations A point mutation is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a DNA or RNA sequence of an organism's genome. Point mutations have a variety of effects on the downstream protein product—consequence ...

missense mutations In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. It is a type of nonsynonymous substitution. Substitution of protein from DNA mutations Missense mu ...

, and

nonsense mutations In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a ''nonsense codon'' in the transcribed mRNA, and in leading to a truncated, incomplete, and usually nonfunctional protein produc ...

. Benzer's work influenced many other scientists of his time (see Phage group). In his molecular biology period, Benzer dissected the fine structure of a single gene, laying down the ground work for decades of mutation analysis and genetic engineering, and setting up a paradigm using the ''rII'' phage that would later be used by

Francis Crick Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was an English molecular biologist, biophysicist, and neuroscientist. He, James Watson, Rosalind Franklin, and Maurice Wilkins played crucial roles in deciphering the helical struc ...

and

Sydney Brenner Sydney Brenner (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to work ...

to establish the triplet code of DNA. In addition, Benzer's mapping technique was taken up by

Richard Feynman Richard Phillips Feynman (; May 11, 1918 – February 15, 1988) was an American theoretical physicist, known for his work in the path integral formulation of quantum mechanics, the theory of quantum electrodynamics, the physics of the superflu ...

. In 1967, Benzer left the field of phage genetics and returned to the California Institute of Technology to work in

behavioral genetics Behavioural genetics, also referred to as behaviour genetics, is a field of scientific research that uses genetic methods to investigate the nature and origins of individual differences in behaviour. While the name "behavioural genetics" c ...

Behavioral genetics

Benzer vs. Hirsch

Benzer was one of the first scientists to rise to prominence in the field of

. As the field began to emerge in the 1960s and 70s, Benzer found himself in scientific opposition to another of the field's leading researchers, Jerry Hirsch. While Hirsch believed that behaviors were complex phenomena irreducible to the level of single genes, Benzer advocated that animal behaviors were not too complex to be directed by a single gene. This translated to methodological differences in the two researchers' experiments with

Drosophila ''Drosophila'' () is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species ...

that profoundly influenced the field of behavioral genetics. Hirsch artificially selected for behaviors of interest over many generations, while Benzer primarily used forward genetic mutagenesis screens to isolate mutants for a particular behavior. Benzer and Hirsch's competing philosophies served to provide necessary scientific tension in order to accelerate and enhance developments in behavioral genetics, helping it gain traction as a legitimate area of study in the scientific community.

Research accomplishments

Benzer used forward genetics to investigate the genetic basis of various behaviors such as

phototaxis Phototaxis is a kind of taxis, or locomotory movement, that occurs when a whole organism moves towards or away from a stimulus of light. This is advantageous for phototrophic organisms as they can orient themselves most efficiently to receive li ...

circadian rhythms A circadian rhythm (), or circadian cycle, is a natural, internal process that regulates the sleep–wake cycle and repeats roughly every 24 hours. It can refer to any process that originates within an organism (i.e., endogenous) and responds to ...

, and learning by inducing mutations in a Drosophila population and then screening individuals for altered phenotypes of interest. To better identify mutants, Benzer developed novel apparatuses such as the countercurrent device, which was designed to separate flies according to the magnitude and direction of their phototactic response. Benzer identified mutants for a wide variety of characteristics: vision (''nonphototactic'', ''negative phototactic'', and ''eyes absent''), locomotion (''sluggish'', ''uncoordinated''), stress sensitivity (''freaked-out''), sexual function (''savoir-faire'', ''

fruitless The ''fruitless'' gene (''fru'') is a ''Drosophila melanogaster'' gene that encodes several variants of a putative transcription factor protein. Normal ''fruitless'' function is required for proper development of several anatomical structures nece ...

''), nerve and muscle function (''photoreceptor degeneration'', ''drop-dead''), and learning and memory (''

rutabaga Rutabaga (; North American English) or swede (British English and some Commonwealth English) is a root vegetable, a form of ''Brassica napus'' (which also includes rapeseed). Other names include Swedish turnip, neep (Scots), and turnip (Scott ...

'', ''dunce''). Benzer and student

Ron Konopka Ronald J. Konopka (1947-2015) was an American geneticist who studied chronobiology. He made his most notable contribution to the field while working with ''Drosophila'' in the lab of Seymour Benzer at the California Institute of Technology. Durin ...

discovered the first circadian rhythm mutants. Three distinct mutant types—arrhythmic, shortened period, and lengthened period—were identified. These mutations all involved the same functional gene on the X chromosome and influenced the eclosion rhythm of the population as well as rhythms in individual flies' locomotor activity. To monitor ''Drosophila'' locomotor activity, Benzer and postdoctoral researcher, Yoshiki Hotta, designed a system using infrared light and solar cells. All three mutations were mapped to the X chromosome, zero centimorgans away from each other, indicating that the mutant phenotypes corresponded to alleles of the same gene, which Konopka named ''

period Period may refer to: Common uses * Era, a length or span of time * Full stop (or period), a punctuation mark Arts, entertainment, and media * Period (music), a concept in musical composition * Periodic sentence (or rhetorical period), a concept ...

''. This was the first of several seminal studies of single genes affecting behavior, studies that have been replicated in other animal models and are now the basis for the growing field of molecular biology of behavior. In 1992 Benzer, working with Michael Rosbash, furthered this work by showing that the PER protein, which ''

'' codes for, is predominantly located in the nucleus. The work with Period mutants was catalytic in the study of circadian rhythms and served to propel the field forward. On 2 October 2017, Dr. Rosbash, along with Drs. Michael W. Young and Jeffrey C. Hall, were awarded the Nobel Prize in Physiology or Medicine in recognition of their cloning of circadian rhythm genes, and the elucidation of the biochemical mechanisms by which the circadian rhythm protein products regulated behavior. Benzer was at the forefront of the study of neurodegeneration in fruit flies, modeling human diseases and attempting to suppress them. He also contributed to the field of aging biology, looking for mutants with altered longevity and trying to dissect the mechanisms by which an organism can escape the inevitable functional downfall and its associated diseases. In 1998, Benzer and his colleagues Yi-Jyun Lin and Laurent Seroude published findings of a long-life mutant in ''Drosophila'', then named Methuselah. The mutant gene coded for a previously unknown member of the

GPCR G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...

family. By testing against temperature stress, it is thought that these mutants have an increased ability to respond to stress and thus to live longer. One of Benzer's final research projects was on dietary restriction and longevity research. A paper was published, in ' 'Cell'', on the longevity effect of 4E-BP, a translational repressor, following dietary restriction. Although the research was done before his death, the paper was published afterwards and dedicated to his memory.

Cancer research

In 1978, Dotty was in the hospital with breast cancer, and Seymour's friend, colleague, and mentor

was diagnosed with cancer. Consequently, Seymour Benzer took interest in cancer biology and attended several conferences on breast cancer. Benzer later remarried with Carol Miller, a

neuropathologist Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology, but work closely with the clinic ...

. Together, in the early 1980s, they used antibody staining techniques to find nearly identical

genes In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

between flies and humans.

Honors and awards

* Fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

(1959) *

Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...

(1964) *

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...

(1971) *

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

(1976), *

Harvey Prize Harvey Prize is an annual Israeli award for breakthroughs in science and technology, as well as contributions to peace in the Middle East granted by the Technion in Haifa. History The prize is named for industrialist and inventor Leo Harvey. T ...

(1977) * Dickson Prize in Science (1978) *

National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...

(1982) *

Rosenstiel Award The Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research is awarded by Brandeis University. It was established in 1971 "as an expression of the conviction that educational institutions have an important role to play in the en ...

(1985) *

Thomas Hunt Morgan Medal The Thomas Hunt Morgan Medal is awarded by the Genetics Society of America (GSA) for lifetime contributions to the field of genetics. The medal is named after Thomas Hunt Morgan, the 1933 Nobel Prize winner, who received this award for his work wi ...

(1986) * Ralph W. Gerard Prize in Neuroscience (1989) *

Wolf Prize in Medicine The Wolf Prize in Medicine is awarded annually by the Wolf Foundation in Israel. It is one of the six Wolf Prizes established by the Foundation and awarded since 1978; the others are in Agriculture, Chemistry, Mathematics, Physics and Arts. The ...

(1991) *

Crafoord Prize The Crafoord Prize is an annual science prize established in 1980 by Holger Crafoord, a Swedish industrialist, and his wife Anna-Greta Crafoord. The Prize is awarded in partnership between the Royal Swedish Academy of Sciences and the Crafoord Foun ...

(1993) *

Feltrinelli Prize The Feltrinelli Prize (from the Italian "Premio Feltrinelli", also known as "International Feltrinelli Prize" or "Antonio Feltrinelli Prize") is an award for achievement in the arts, music, literature, history, philosophy, medicine, and physical and ...

(1994) *

International Prize for Biology The is an annual award for "outstanding contribution to the advancement of research in fundamental biology." The Prize, although it is not always awarded to a biologist, is one of the most prestigious honours a natural scientist can receive. Ther ...

(2000) *

NAS Award in the Neurosciences The NAS Award in the Neurosciences is awarded by the U.S. National Academy of Sciences "in recognition of extraordinary contributions to progress in the fields of neuroscience, including neurochemistry, neurophysiology, neuropharmacology, devel ...

from the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

(2001) *

March of Dimes Prize in Developmental Biology The March of Dimes Prize in Developmental Biology is awarded once a year by the March of Dimes. It carries a $250,000 award "to an investigator whose research brings us closer to the day when all babies will be born healthy." It also includes a ...

(2002) *

(2004) (second award) * Bower Award and Prize for Achievement in Science (2004) *

Albany Medical Center Prize The Albany Medical Center Prize in Medicine and Biomedical Research is the United States' second highest value prize in medicine and biomedical research, awarded by the Albany Medical Center. Among prizes for medicine worldwide, the Albany Medical ...

(2006) He was a member of the

French Academy of Sciences The French Academy of Sciences (French: ''Académie des sciences'') is a learned society, founded in 1666 by Louis XIV of France, Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French Scientific me ...

, the U.S. National Academy of Sciences, the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

and the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

Books

Benzer is the subject of the 1999 book ''

Time, Love, Memory ''Time, Love, Memory: A Great Biologist and His Quest for the Origins of Behavior'' is a book by American non-fiction writer Jonathan Weiner, published in 1999. The book is a biography of California Institute of Technology biologist Seymour Ben ...

: A Great Biologist and His Quest for the Origins of Behavior'' by Pulitzer laureate

Jonathan Weiner Jonathan Weiner (born November 26, 1953) is an American writer of non-fiction books based on his biological observations, focusing particularly on evolution in the Galápagos Islands, genetics, and the environment. His latest book is ''Long for ...

, and ''Reconceiving the Gene: Seymour Benzer's Adventures in Phage Genetics'' by Lawrence Holmes.

References

External links

Obituary in ''The Times''
12 December 2007
Interview with Seymour Benzer
conducted by the Oral History Project of the Caltech Archives
National Academy of Sciences Biographical Memoir
{{DEFAULTSORT:Benzer, Seymour 1921 births 2007 deaths American geneticists American people of Polish-Jewish descent 20th-century American physicists Behavior geneticists California Institute of Technology faculty Fellows of the American Academy of Arts and Sciences Foreign Members of the Royal Society History of genetics Jewish American scientists Jewish physicists Members of the French Academy of Sciences Members of the United States National Academy of Sciences American molecular biologists National Medal of Science laureates Phage workers Purdue University alumni Wolf Prize in Medicine laureates Recipients of the Albert Lasker Award for Basic Medical Research People from Bensonhurst, Brooklyn Scientists from New York (state) New Utrecht High School alumni Brooklyn College alumni 20th-century American Jews