Set1 is a gene that codes for Histone-lysine N-methyltransferase and H3 lysine-4 specific proteins ( H3K). Set1 proteins can also be referred to as

COMPASS A compass is a device that shows the cardinal directions used for navigation and geographic orientation. It commonly consists of a magnetized needle or other element, such as a compass card or compass rose, which can pivot to align itself wit ...

proteins. The first H3K4 methylase, ''Saccharomyces cerevisiae'' Set1/COMPASS, is highly conserved across a multitude of phylogenies. The histone methylation facilitated by Set1 is required for cell growth and transcription silencing through the repression of

RNA polymerase II RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryo ...

. The Set1C, COMPASS Complex, also aids in transcription elongation regulation and the maintenance of telomere length.

References

Genes {{Gene-stub