The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with

sepsis Sepsis, formerly known as septicemia (septicaemia in British English) or blood poisoning, is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage is follo ...

. Drawn from international guidelines that emerged from the

Surviving Sepsis Campaign The Surviving Sepsis Campaign (SSC) is a global initiative to bring together professional organizations in reducing mortality from sepsis. The purpose of the SSC is to create an international collaborative effort to improve the treatment of sepsis ...

the Sepsis Six was developed by The UK Sepsis Trust. (Daniels, Nutbeam, Laver) in 2006 as a practical tool to help healthcare professionals deliver the basics of care rapidly and reliably. In 2011, The UK Sepsis Trust published evidence that use of the Sepsis Six was associated with a 50% reduction in

mortality Mortality is the state of being mortal, or susceptible to death; the opposite of immortality. Mortality may also refer to: * Fish mortality, a parameter used in fisheries population dynamics to account for the loss of fish in a fish stock throug ...

, a decreased length of stay in hospital, and fewer

intensive care Intensive care medicine, also called critical care medicine, is a medical specialty that deals with seriously or critically ill patients who have, are at risk of, or are recovering from conditions that may be life-threatening. It includes pro ...

days. Though the authors urge caution in a causal interpretation of these findings. The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis: # Titrate

oxygen Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group in the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements as wel ...

to a saturation target of 94% # Take

blood cultures A blood culture is a medical laboratory test used to detect bacteria or fungi in a person's blood. Under normal conditions, the blood does not contain microorganisms: their presence can indicate a bloodstream infection such as bacteremia or ...

and consider source control # Administer empiric intravenous

antibiotics An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention o ...

# Measure serial serum

lactates Lactate may refer to: * Lactation, the secretion of milk from the mammary glands * Lactate, the conjugate base of lactic acid Lactic acid is an organic acid. It has a molecular formula . It is white in the solid state and it is miscible with ...

# Start

intravenous fluid Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutrie ...

resuscitation # Commence accurate

urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excretion, excreted from the body through the urethra. Cel ...

output measurement.

References

{{reflist, refs= {{cite web, url=http://sepsistrust.org/, title=Home « The UK Sepsis Trust The UK Sepsis Trust, publisher=sepsistrust.org, accessdate=2014-04-22 {{cite journal , publisher=Society of Critical Care Medicine/Lippincott Williams & Wilkins , issn=00903493 , editor1-first=Timothy G. , editor1-last=Buchanan , editor2-first=Sophie M. , editor2-last=Tosta , editor3-first=Lynn , editor3-last=Retford , editor4-first=Jill , editor4-last=Goldberg , editor5-first=Sarah , editor5-last=Less , editor6-first=Madison , editor6-last=Drake , editor7-first=David M. , editor7-last=Maslove , editor8-first=Clifford S. , editor8-last=Deutschmann , editor9-first=Donald S. , editor9-last=Prough , oclc=772657699 , lccn=73647665 , url=https://pubmed.ncbi.nlm.nih.gov/18158437/ , volume=36 , issue=1 , pages=296–327 , title=Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008 , date=1 January 2008 , journal=

Critical Care Medicine Intensive care medicine, also called critical care medicine, is a medical specialty that deals with seriously or critically ill patients who have, are at risk of, or are recovering from conditions that may be life-threatening. It includes pro ...

, doi=10.1097/01.ccm.0000298158.12101.41 , pmid=18158437 , last1=R. Phillip , first1=Dellinger , last2=Mitchell M. , first2=Levy , last3=Jean M. , first3=Carlet , last4=Julian , first4=Bion , last5=Margaret M. , first5=Parker , last6=Roman , first6=Jaeschke , last7=Konrad , first7=Reinhart , last8=Derek C. , first8=Angus , last9=Christian , first9=Brun-Buisson , last10=Richard , first10=Beale , last11=Thierry , first11=Calandra , last12=Jean-Francois , first12=Dhainaut , last13=Herwig , first13=Gerlach , last14=Maurene , first14=Harvey , last15=John J. , first15=Marini , last16=John , first16=Marshall , last17=Marco , first17=Ranieri , last18=Graham , first18=Ramsay , last19=Jonathan , first19=Sevransky , last20=B. Taylor , first20=Thompson , last21=Sean , first21=Townsend , last22=Jeffrey S. , first22=Vender , last23=Janice L. , first23=Zimmerman , last24=Jean-Louis , first24=Vincent , s2cid=220581728 , display-authors=10 , via=

PubMed PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the ...

, archive-date=16 June 2020 , archive-url=https://web.archive.org/web/20200616000957/https://pubmed.ncbi.nlm.nih.gov/18158437 {{cite journal , publisher=

Society of Critical Care Medicine The Society of Critical Care Medicine (SCCM) is the largest non-profit medical organization in the practice of critical care. SCCM was established in 1970 and is an independently incorporated, international, educational and scientific society base ...

Lippincott Williams & Wilkins Lippincott Williams & Wilkins (LWW) is an American imprint of the American Dutch publishing conglomerate Wolters Kluwer. It was established by the acquisition of Williams & Wilkins and its merger with J.B. Lippincott Company in 1998. Under the LW ...

, issn=00903493 , editor1-first=Timothy G. , editor1-last=Buchanan , editor2-first=Sophie M. , editor2-last=Tosta , editor3-first=Lynn , editor3-last=Retford , editor4-first=Jill , editor4-last=Goldberg , editor5-first=Sarah , editor5-last=Less , editor6-first=Madison , editor6-last=Drake , editor7-first=David M. , editor7-last=Maslove , editor8-first=Clifford S. , editor8-last=Deutschmann , editor9-first=Donald S. , editor9-last=Prough , oclc=772657699 , lccn=73647665 , journal=

, title=Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 , last1=Rhodes , first1=Andrew , last2=Evans , first2=Laura E. , last3=Alhazzani , first3=Waleed , last4=Levy , first4=Mitchell M. , last5=Antonelli , first5=Massimo , last6=Ferrer , first6=Ricard , last7=Kumar , first7=Anand , last8=Sevransky , first8=Jonathan E. , last9=Sprung , first9=Charles L. , last10=Nunnally , first10=Mark E. , last11=Rochwerg , first11=Bram , last12=Rubenfeld , first12=Gordon D. , last13=Angus , first13=Derek C. , last14=Annane , first14=Djillali , last15=Beale , first15=Richard J. , last16=Bellinghan , first16=Geoffrey J. , last17=Bernard , first17=Gordon R. , last18=Chiche , first18=Jean-Daniel , last19=Coopersmith , first19=Craig , last20=De Backer , first20=Daniel P. , last21=French , first21=Craig J. , last22=Fujishima , first22=Seitaro , last23=Gerlach , first23=Herwig , last24=Hidalgo , first24=Jorge Luis , last25=Hollenberg , first25=Steven M. , last26=Jones , first26=Alan E. , last27=Karnad , first27=Dilip R. , last28=Kleinpell , first28=Ruth M. , last29=Koh , first29=Younsuck , last30=Lisboa , first30=Thiago Costa , last31=Machado , first31=Flavia R. , last32=Marini , first32=John J. , last33=Marshall , first33=John C. , last34=Mazuski , first34=John E. , last35=McIntyre , first35=Lauralyn A. , last36=McLean , first36=Anthony S. , last37=Mehta , first37=Sangeeta , last38=Moreno , first38=Rui P. , last39=Myburgh , first39=John , last40=Navalesi , first40=Paolo , last41=Nishida , first41=Osamu , last42=Osborn , first42=Tiffany M. , last43=Perner , first43=Anders , last44=Plunkett , first44=Colleen , last45=Ranieri , first45=Marco , last46=Schorr , first46=Christa A. , last47=Seckel , first47=Maureen A. , last48=Seymour , first48=Christopher W. , last49=Shieh , first49=Lisa , last50=Shukri , first50=Khalid A. , last51=Simpson , first51=Steven Q. , last52=Singer , first52=Mervyn , last53=Thompson , first53=B. Taylor , last54=Townsend , first54=Sean R. , last55=Van der Poll , first55=Thomas , last56=Vincent , first56=Jean-Louis , last57=Wiersinga , first57=W. Joost , last58=Zimmerman , first58=Janice L. , last59=Dellinger , first59=R. Phillip , doi=10.1097/CCM.0000000000002255 , volume=45 , issue=3 , date=1 March 2017 , pages=486–452 , pmid=28098591 , s2cid=52827184 , url=https://dx.doi.org/10.1097/CCM.0000000000002255 , access-date=22 June 2021 , archive-date=1 February 2020 , archive-url=https://web.archive.org/web/20200201033129/https://journals.lww.com/ccmjournal/Fulltext/2017/03000/Surviving_Sepsis_Campaign__International.15.aspx , language=English , display-authors=10 {{cite journal, last1=Daniels , first1=Ron , last2=Nutbeam , first2=Tim , last3=McNamara , first3=Georgina , last4=Galvin , first4=Clare , date=2011 , title=The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study , journal=Emergency Medicine Journal , volume=28 , issue=6 , pages=507–512 , doi=10.1136/emj.2010.095067 , issn=14720213 , pmid=21036796 , url=https://emj.bmj.com/content/28/6/507 , archive-date=2 June 2018 , archive-url=https://web.archive.org/web/20180602062804/https://emj.bmj.com/content/28/6/507 , publication-place=

London London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...

England England is a country that is part of the United Kingdom. It shares land borders with Wales to its west and Scotland to its north. The Irish Sea lies northwest and the Celtic Sea to the southwest. It is separated from continental Europe b ...

, United Kingdom of Great Britain , lccn=97640199 , jstor=09598138 , oclc=32595642 , publisher=

BMJ Publishing Group Ltd BMJ (branded as BMJ Group until 2013) is a British publisher of medical journals. Established in 1840, the company is owned by the British Medical Association. Publications * 1840: '' Provincial Medical and Surgical Journal'' (later renamed t ...

British Medical Association The British Medical Association (BMA) is a registered trade union for doctors in the United Kingdom. The association does not regulate or certify doctors, a responsibility which lies with the General Medical Council. The association's headquar ...

, s2cid=26693613 , editor1-first=Fiona , editor1-last=Godlee , editor1-link=Fiona Godlee , editor2-first=Kamran , editor2-last=Abbasi , editor3-first=Theodora , editor3-last=Bloom , editor4-first=Elizabeth , editor4-last=Loder , editor5-first=Rebecca , editor5-last=Coombes , editor6-first=Juliet , editor6-last=Dobson , editor7-first=Zosia , editor7-last=Kmietowicz , editor8-first=Paul , editor8-last=Simpson , editor9-first=Alison , editor9-last=Tonks , editor10-first=Tom , editor10-last=Moberly , editor11-first=Kelly , editor11-last=Brendel , editor12-first=Isaac , editor12-last=Jones , display-editors=10 Medical procedures Sepsis