Selmar Aschheim (4 October 1878 – 15 February 1965) was a German

gynecologist Gynaecology or gynecology (see spelling differences) is the area of medicine that involves the treatment of women's diseases, especially those of the reproductive organs. It is often paired with the field of obstetrics, forming the combined ...

who was a native resident of

Berlin Berlin ( , ) is the capital and List of cities in Germany by population, largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's List of cities in the European Union by population within ci ...

. Born into a

Jewish Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The ...

family, in 1902 he received a doctorate of medicine in

Freiburg Freiburg im Breisgau (; abbreviated as Freiburg i. Br. or Freiburg i. B.; Low Alemannic: ''Friburg im Brisgau''), commonly referred to as Freiburg, is an independent city in Baden-Württemberg, Germany. With a population of about 230,000 (as o ...

, and later became director of the laboratory of the ''Universitäts-Frauenklinik'' at the Berlin Charité. In 1930 Aschheim attained the chair of biological research in gynecology at the

University of Berlin Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative ...

. In 1933 he fled

Nazi Germany Nazi Germany (lit. "National Socialist State"), ' (lit. "Nazi State") for short; also ' (lit. "National Socialist Germany") (officially known as the German Reich from 1933 until 1943, and the Greater German Reich from 1943 to 1945) was ...

and moved to

Paris Paris () is the Capital city, capital and List of communes in France with over 20,000 inhabitants, most populous city of France, with an estimated population of 2,165,423 residents in 2019 in an area of more than 105 km² (41 sq mi), ma ...

, where he worked in medical research at the Hôpital Beaujon. Aschheim was a specialist concerning gynecological

histology Histology, also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures vi ...

and

hormone A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are require ...

research. In 1928 with

endocrinologist Endocrinology (from ''endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events ...

Bernhard Zondek Bernhard Zondek ( he, ברנרד צונדק; 29 July 1891 – 8 November 1966) was a German-born Israeli gynecologist who developed the first reliable pregnancy test in 1928. Biography Bernhard Zondek was born in Wronke, Germany, now Wronki, Po ...

(1891–1966), he isolated the

gonadotropic Gonadotropins are glycoprotein hormones secreted by gonadotropic cells of the anterior pituitary of vertebrates. This family includes the mammalian hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), the placental/chorio ...

hormone known as

human chorionic gonadotropin Human chorionic gonadotropin (hCG) is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo (syncytiotrophoblast initially), which eventually forms the placenta after implantatio ...

(hCG), which was discovered in the

urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra. Cellular ...

of pregnant women. From their research the "Aschheim-Zondek test" for

pregnancy Pregnancy is the time during which one or more offspring develops (gestation, gestates) inside a woman, woman's uterus (womb). A multiple birth, multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occur ...

was created, which involved injection of a patient's urine into an immature laboratory mouse. If the rodent displayed an

estrous The estrous cycle (, originally ) is the set of recurring physiological changes that are induced by reproductive hormones in most mammalian therian females. Estrous cycles start after sexual maturity in females and are interrupted by anestrous p ...

reaction, it represented a positive indication of pregnancy. The two doctors published the findings of the hormone in a treatise titled ''Das Hormon des Hypophysenvorderlappens''. At the time they believed that the gonadotrophin was produced by the anterior pituitary, however further research in the 1940s demonstrated that the

placenta The placenta is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation. It plays critical roles in facilitating nutrient, gas and waste exchange between the physically separate mate ...

was responsible for the elaboration of the hormone.

References

External links

Historical perspectives in gonadotrophin therapy
by Bruno Lunenfeld

@

Who Named It ''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliograp ...

{{DEFAULTSORT:Aschheim, Selmar 1878 births 1965 deaths Jewish emigrants from Nazi Germany to France German gynaecologists University of Freiburg alumni Academic staff of the Humboldt University of Berlin Members of the German Academy of Sciences at Berlin Physicians of the Charité