Sauvagine is a
neuropeptide
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...
from the
corticotropin-releasing factor
Corticotropin-releasing factor family, CRF family is a family of related neuropeptides in vertebrates. This family includes corticotropin-releasing hormone (also known as CRF), urotensin-I, urocortin, and sauvagine. The family can be grouped int ...
(CRF) family of peptides and is
orthologous
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a spec ...
to the mammalian hormone,
urocortin 1, and the
teleost
Teleostei (; Greek ''teleios'' "complete" + ''osteon'' "bone"), members of which are known as teleosts ), is, by far, the largest infraclass in the class Actinopterygii, the ray-finned fishes, containing 96% of all extant species of fish. Tel ...
fish hormone, urotensin 1.
It is 40 amino acids in length,
and has the sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog ''
Phyllomedusa sauvagii
''Phyllomedusa sauvagii'', the waxy monkey leaf frog or waxy monkey tree frog, is a species of frog in the subfamily Phyllomedusinae. It is native to South America, where it occurs in Argentina, Bolivia, Paraguay and Brazil. This species is arbor ...
.'' Given its relation to other CRF-related peptides, it exerts similar physiological effects as
corticotropin-releasing hormone
Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress (biology), stress responses. It is a releasing ...
.
Sauvagine belongs to the
corticotropin-releasing factor
Corticotropin-releasing factor family, CRF family is a family of related neuropeptides in vertebrates. This family includes corticotropin-releasing hormone (also known as CRF), urotensin-I, urocortin, and sauvagine. The family can be grouped int ...
(CRF) family that also includes
CRF,
urocortin l/urotensin l,
urocortin II
Urocortin 2 (Ucn2) is an endogenous peptide in the corticotrophin-releasing factor (CRF) family.
Urocortin II is a 38-amino acid peptide that is a member of the CRF family of peptides. Unlike Urocortin I, Urocortin II is highly selective for th ...
and
urocortin III
Urocortin III is a 38 amino acid peptide that is a member of the CRF family of peptides. Unlike Urocortin I, and similar to Urocortin II, Urocortin III is highly selective for the CRF2 receptor and does not show affinity for the CRF binding prot ...
.
Interactions
Sauvagine has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
corticotropin releasing factor receptors
1 and
2, and (as with other CRF-related peptides) is also bound by the
corticotropin-releasing factor binding protein.
References
Corticotropin-releasing hormone receptor agonists
Peptide hormones
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