The surname Santayana may refer to
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George Santayana
Jorge Agustín Nicolás Ruiz de Santayana y Borrás, known in English as George Santayana (; December 16, 1863 – September 26, 1952), was a Spanish and US-American philosopher, essayist, poet, and novelist. Born in Spain, Santayana was raised ...
(1863-1952), a Spanish-American philosopher
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Antonio Gutiérrez de Otero y Santayana (1729-1799), a Spanish Lieutenant General best known for repelling Admiral Nelson's attack on Santa Cruz de Tenerife in 1797
Spanish-language surnames
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