Education
Ghosh received hisCareer
After his success at the Baltimore lab, Ghosh began his independent research career at Yale University School of Medicine in 1991, serving as a professor in the Departments of Immunobiology and Molecular Biophysics & Biochemistry. At Yale, Ghosh's laboratory made numerous original findings that helped establish the mechanism of transcriptional regulation of NF-κB proteins, identification and characterization of signaling intermediates in innate and adaptive immune system, and identification and characterization of a subset ofBibliography
* ''Initiation factors in eukaryotic protein synthesis''. Sue Golding Graduate Division of Medical Sciences, Albert Einstein College of Medicine, Yeshiva University, 1988. *Selected publications
* Seeley, J.J., Baker, R.G., Mohamed, G., Bruns, T., Hayden, M.S., Deshmukh, S.D., Freedberg, D.E and Ghosh, S. (2018) Induction of innate immune memory via microRNA targeting of chromatin remodelling factors. ''Nature'' 559: 114–119. * Grinberg-Bleyer, Y., Caron, R., Seeley, J.J., De Silva, N.S., Schindler, C.W., Hayden, M.S., Klein, U. and Ghosh, S. (2018) The alternative NF-κB pathway in regulatory T cell homeostasis and suppressive function. ''J. Immunol.'' 200: 2362–2371. (Cover article) * Carneiro, F.R.G., Lepelley, A., Seeley, J.J., Hayden, M.S. and Ghosh, S. (2018) An essential role for ECSIT in mitochondrial complex I assembly and mitophagy in macrophages. ''Cell Rep.'' 22:2654-2666. * Oh, H., Grinberg-Bleyer, Y., Liao, W., Maloney, D., Wang, P., Wu, Z., Wang, J., Bhatt, D.M., Heise, N., Schmid, R.M., Hayden, M.S., Klein, U., Rabadan, R., and Ghosh, S. (2017) An NF-κB transcription-factor-dependent lineage-specific transcriptional program promotes regulatory T cell identity and function. ''Immunity'' 47: 450–465. * Grinberg-Bleyer, Y., Oh, H., Desrichard, A., Bhatt, D.M., Caron, R., Chan, T.A., Schmid, R.M., Klein, U., Hayden, M.S. and Ghosh, S. (2017) NF-κB c-Rel is crucial for the regulatory T cell immune checkpoint in cancer. ''Cell'' 170: 1096–1108. * Dainichi, T., Hayden, M.S., Park, S.-G., Oh, H., Seeley, J.J., Grinberg-Bleyer, Y., Beck, K.M., Miyachi, Y., Kabashima, K., Hashimoto, T. and Ghosh, S. (2016) PDK1 is a regulator of epidermal differentiation that activates and organizes asymmetric cell division. ''Cell Rep.'' 15: 1–9. * Castellanos-Rubio, A., Fernandez-Jimenez, N., Kratchmarov, R., Luo, X., Bhagat, G., Green, P.H.R., Schneider, R., Kiledjian, M., Bilbao, J.R. and Ghosh, S. (2016) A long noncoding RNA associated with susceptibility to celiac disease. ''Science'' 352: 91–95. * Grinberg-Bleyer, Y., Dainichi, T., Oh, H., Heise, N., Klein, U., Schmid, R.M., Hayden, M.S. and Ghosh, S. (2015) Cutting edge: NF-kappaB p65 and c-Rel control epidermal development and immune homeostasis in the skin. ''J. Immunol.'' 194: 2472–2476. * Oeckinghaus, A., Postler, T.S., Rao, P., Schmitt, H., Schmitt, V., Grinberg-Bleyer, Y., Kuhn, L.I., Gruber, C.W., Lienhard, G.E. and Ghosh S. (2014) kB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation. ''Cell Rep.'' 8: 1793–1807. * Koblansky, A.A., Jankovic, D., Oh, H., Hieny, S., Sungnak, W., Mathur, R., Hayden, M.S., Akira, S., Sher, A. and Ghosh, S. (2013) Recognition of profilin by Toll-like receptor 12 is critical for host resistance to ''Toxoplasma gondii. Immunity'' 38: 119–130. * Mathur, R., Oh, H., Zhang, D., Park, S.-G., Seo, J., Koblansky, A., Hayden, M.S. and Ghosh, S. (2012) A mouse model of ''Salmonella'' Typhi infection. ''Cell'' 151: 590–602. * West, A.P., Brodsky, I.E., Rahner, C., Woo, D.K., Erdjument-Bromage, H., Tempst, P., Walsh, M.C., Choi, Y., Shadel, G.S. and Ghosh, S. (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. ''Nature'' 472: 476–480. * Park, S.G., Mathur, R., Long, M., Hosh, N., Hao, L., Hayden, M.S. and Ghosh, S. (2010) T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells. ''Immunity'' 33: 791–803. * Rao, P., Hayden, M.S., Long, M., Scott, M.L., Philip West, A., Zhang, D., Oeckinghaus, A., Lynch, C., Hoffmann, A., Baltimore, D. and Ghosh, S. (2010) IkBβ acts to inhibit and activate gene expression during the inflammatory response. ''Nature'' 466: 1115–1119. * Dong, J., Jimi E., Zeiss C., Hayden M.S. and Ghosh, S. (2010) Constitutively active NF-κB triggers systemic TNFα-dependent inflammation and localized TNFα-independent inflammatory disease. ''Genes & Development'' 24: 1709–1717. * Long, M., Park, S.-G., Strickland, I., Hayden, M.S. and Ghosh, S. (2009) Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. ''Immunity'' 18: 921–931. * Park, S.-G., Schulze-Luehrman, J., Hayden, M.S., Hashimoto, N., Ogawa, W., Kasuga, M. and Ghosh, S. (2009) PDK1 integrates TCR and CD28 signaling to NF-κB. ''Nature Immunology'' 10: 158–166. * Jimi, E., Voll, R. E., Strickland, I., Long, M. and Ghosh, S. (2008) Differential role of NF-κB in selection and survival of CD4 and CD8 thymocytes. ''Immunity'' 29: 523–537. * Dong, J., Jimi, E., Zhong, H., Hayden, M.S. and Ghosh S. (2008) Epigenetic regulation of NF-κB dependent gene expression. ''Genes & Development'' 22: 1159–1173. * Shim, J.-H., Xiao, C., Paschal, A., Bailey, S.T., Rao, P., Hayden, M.S., Lee, K.Y., Bussey, C., Steckel, M., Tanaka, N., Akira, S., Yamada, G., Matsumoto, S. and Ghosh, S. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways ''in vivo. Genes & Development'' 19: 2668–2681. * Yarovinsky, F., Zhang, D., Andersen, J.F., Bannenberg, G.L., Serhan, C.N., Hayden, M.S., Hieny, S., Sutterwala, F., Flavell, R. A., Ghosh, S. and Sher, A. (2005) TLR11 activation of dendritic cells by a protozoan profilin-like protein. ''Science'' 308: 1626–1629. * Lee, K.-Y., D'Acquisto, F., Hayden, M.S., Shim, J.-H. and Ghosh, S. (2005) Protein kinase PDK1 nucleates T-cell receptor-induced signaling complex for NF-κB activation. ''Science'' 308: 114–118. * Jimi, E., Aoki, K., Saito, H., D'Acquisto, F., May, M.J., Ichiro Nakamura, I., Sudo, T., Ohya, K. and Ghosh, S. (2004) Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction ''in vivo. Nature Medicine'' 10: 617–624. * Zhang, D., Zhang, G., Hayden, M.S., Greenblatt, M.S., Bussey, C., Flavell, R.A. and Ghosh, S. (2004) A novel Toll-like receptor that prevents infection of kidneys by uropathogenic bacteria. ''Science'' 303: 1522–1526. * Xiao, C., Shim, J-H., Kluppel, M., Zhang, S-M., Dong, C., Flavell, R.A., Fu, X-Y., Wrana, J. L., Hogan, B.L.M. and Ghosh, S. (2003) Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. ''Genes & Development'' 17: 2933–2949. * Zhong, H., May, M.J., Jimi, E. and Ghosh, S. (2002) Phosphorylation of nuclear NF-κB governs its association with either HDAC-1 or CBP/p300: a mechanism for regulating the transcriptional activity of NF-κB. ''Molecular Cell'' 9: 625–636. * May, M.J., D'Acquisto, F., Madge, L.A., Gloeckner, J., Pober, J.S. and Ghosh, S. (2000) Selective inhibition of NFk-B activation by a peptide that blocks the interaction of NEMO with the IkB kinase complex. ''Science'' 289: 1550–1554. * Voll, R.E., Jimi, E., Phillips, R.J., Barber, D.F., Rincon. M., Hayday, A.C., Flavell, R.A. and Ghosh, S. (2000) NFk-B Activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. ''Immunity'' 13: 677–689. * Fenwick, C., Na, S-Y., Voll, R.E., Zhong, H., Im, S-Y., Lee, J.W. and Ghosh, S. (2000) A sub-class of Ras proteins that regulate the degradation of IkappaB. ''Science'' 287: 869–873. * Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C.A. and Ghosh, S. (1999) ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. ''Genes & Development'' 13: 2059–2071. * Medzhitov, R., Kopp, E.B., Ghosh, S. and Janeway, C.A. (1998) MyD88 is a common intermediate in the IL-1 and Toll signal transduction pathways. ''Molecular Cell'' 2: 253–258. * Zhong, H., Voll, R.E. and Ghosh, S. (1998) Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the co-activator CBP/p300. ''Molecular Cell'' 1: 661–671. * Zhong, H., SuYang, H., Erdjument-Bromage, H., Tempst, P. and Ghosh, S. (1997) The transcriptional activity of NF-κB is regulated by IkB-associated PKAc subunit through a cyclic AMP independent mechanism. ''Cell'' 89: 413–424. * Beg, A.A., Sha, W.C., Bronson, R.T., Ghosh, S. and Baltimore, D. (1995) Embyronic lethality and liver degeneration in mice lacking the RelA component of NF-κB. ''Nature'' 376: 167–170. * Ghosh, G., Van Duyne, G., Ghosh, S. and Sigler, P.B. (1995) Structure of NF-kappa B p50 homodimer bound to a kappa B site. ''Nature'' 373: 303–310. * Thompson, J.E., Phillips, R.J., Erdjument-Bromage, H., Tempst, P. and Ghosh, S. (1995) IkB-ß regulates the persistent response in a biphasic activation of NFk-B. ''Cell'' 80: 573–582. * Kopp, E. and Ghosh, S. (1994) Inhibition of NF-κB by sodium salicylate and aspirin. ''Science''265: 956–959. * Davis, N.*, Ghosh, S.*, Simmons, D.L., Tempst, P., Liou, H.C., Baltimore, D. and Bose, H.R. Jr. (1991) Rel-associated pp40 (IkappaB alpha): an inhibitor of the rel family of transcription factors. ''Science'' 253: 1268–1271. (*equal contribution) * Nolan, G.P., Ghosh, S., Liou, H.C., Tempst, P. and Baltimore, D. (1991) DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. ''Cell''64: 961–969. * Ghosh, S., Gifford, A.M., Riviere, L.R., Tempst, P., Nolan, G.P. and Baltimore, D. (1990) Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. ''Cell'' 62: 1019–1029. * Ghosh, S. and Baltimore, D. (1990) Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. ''Nature'' 344: 678–682.References
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