The Lunenfeld-Tanenbaum Research Institute is a

medical Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practic ...

research institute A research institute, research centre, research center or research organization, is an establishment founded for doing research. Research institutes may specialize in basic research or may be oriented to applied research. Although the term often i ...

Toronto Toronto ( ; or ) is the capital city of the Canadian province of Ontario. With a recorded population of 2,794,356 in 2021, it is the most populous city in Canada and the fourth most populous city in North America. The city is the ancho ...

Ontario Ontario ( ; ) is one of the thirteen provinces and territories of Canada.Ontario is located in the geographic eastern half of Canada, but it has historically and politically been considered to be part of Central Canada. Located in Central Ca ...

and part of the

Sinai Health System The Sinai Health is a hospital system which serves Toronto, Ontario, Canada. It comprises two hospitals, Mount Sinai Hospital (Toronto), Mount Sinai Hospital (an acute care hospital) and Hennick Bridgepoint Hospital, formally Bridgepoint Active H ...

. It was originally established in 1985 as the Samuel Lunenfeld Research Institute, the research arm of Mount Sinai Hospital, by an endowment from the Lunenfeld and Kunin families. It was renamed to the current name on June 24, 2013, after a $35 million donation from Larry and Judy Tanenbaum. It comprises 36 principal investigators, has a budget of C$90 million (2005/6), has over 200 trainees and approximately 600 staff.Researchers
/ref> The institute conducts research into various forms of cancer ( colon,

breast The breast is one of two prominences located on the upper ventral region of a primate's torso. Both females and males develop breasts from the same embryological tissues. In females, it serves as the mammary gland, which produces and secret ...

pancreatic The pancreas is an Organ (anatomy), organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdominal cavity, abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine ...

prostate The prostate is both an Male accessory gland, accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation. It is found only in some mammals. It differs between species anatomically, ...

lung The lungs are the primary organs of the respiratory system in humans and most other animals, including some snails and a small number of fish. In mammals and most other vertebrates, two lungs are located near the backbone on either side of t ...

, etc.),

neurological disorders A neurological disorder is any disorder of the nervous system. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms. Examples of symptoms include paralysis, muscle weakness ...

and brain illnesses,

women's A woman is an adult female human. Prior to adulthood, a female human is referred to as a girl (a female child or adolescent). The plural ''women'' is sometimes used in certain phrases such as "women's rights" to denote female humans regardl ...

and infants' health,

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

developmental biology Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and di ...

stem cell In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type o ...

biology and

tissue regeneration In biology, regeneration is the process of renewal, restoration, and tissue growth that makes genomes, cells, organisms, and ecosystems resilient to natural fluctuations or events that cause disturbance or damage. Every species is capable of rege ...

mouse models of human disease A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...

genomic medicine Medical genetics is the branch tics in that human genetics is a field of scientific research that may or may not apply to medicine, while medical genetics refers to the application of genetics to medical care. For example, research on the caus ...

and

systems biology Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological syst ...

. The institute has of space and is split between the main hospital and the Joseph and Wolf Lebovic Health Complex. The Lunenfeld-Tanenbaum Research Institute is a world pioneer in the fields of

Systems Biology Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological syst ...

Diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

, and Infectious Bowel Disease. Its Systems Biology team consistently ranked Top 5 worldwide. Researchers at the Lunenfeld have the highest per capita funding and citations in Canada. The founding director was

Louis Siminovitch Louis Siminovitch (May 1, 1920 – April 6, 2021) was a Canadian molecular biologist. He was a pioneer in human genetics, researcher into the genetic basis of muscular dystrophy and cystic fibrosis, and helped establish Ontario programs explor ...

(1984–1994), followed by

Alan Bernstein Alan Bernstein (born June 25, 1947) is president and CEO of CIFAR (the Canadian Institute for Advanced Research). He is recognized as a leader in health research, science policy, mentorship and organizational leadership. Education Born in Toront ...

(1995–2000), Janet Rossant and

Anthony Pawson Anthony James Pawson (18 October 1952 – 7 August 2013) was a British-born Canadian scientist whose research revolutionised the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how the ...

(2001–2002),

(2002–2005) and James Woodgett (2005–). Researchers are supported by the Mount Sinai Hospital Foundation, donors and external funding sources including the

Canadian Institutes of Health Research The Canadian Institutes of Health Research (CIHR; french: Instituts de recherche en santé du Canada; IRSC) is a federal agency responsible for funding health and medical research in Canada. Comprising 13 institutes, it is the successor to the M ...

Canadian Cancer Society The Canadian Cancer Society (french: Société canadienne du cancer) is Canada's largest national cancer charity and the largest national charitable funder of cancer research in Canada. History The idea to form the Canadian Cancer Society origin ...

Terry Fox Foundation The Terry Fox Run is an annual non-competitive charity event held around the world to raise money for cancer research in commemoration of Canadian cancer activist Terry Fox and his Marathon of Hope. The event was founded in 1981 by Isadore Sharp ...

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

and

Genome Canada Genome Canada is a non-profit organization that aims to use genomics-based technologies to improve the lives of Canadians. It is funded by the Government of Canada. Genome Canada provides large-scale investments that develop new technologies, conne ...

References

External links

* {{authority control Medical research institutes in Canada Laboratories in Canada Research institutes established in 1985 1985 establishments in Ontario