Samp1, is an
inner nuclear membrane protein
Inner nuclear membrane proteins (INM proteins) are membrane proteins that are embedded in or associated with the inner membrane of the nuclear envelope. There are about 60 INM proteins, most of which are poorly characterized with respect to stru ...
in mammals. Samp1 is known to interact with SUN2 and
lamin A/C, and is believed to be involved in the stabilizing of the LINC complex during cell mitosis, facilitating the anchoring to the lamina. Lamin A/C is required for samp1 presence at the inner nuclear membrane. Samp1 is homologous to the
''S. Pombe'' inner nuclear membrane protein Ima1.
[Joana Borrego-Pinto et al.(2012) "Samp1 is a component of TAN lines and is required for nuclear movement"Journal of Cell Science 125, 1-7 doi= 10.1242/jcs.087049]
References
{{Reflist
Molecular biology