Sam Granick (February 16, 1909 – April 29, 1977) was an American
biochemist known for his studies of
ferritin
Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including archaea, bacteria, algae, higher plants, and animals. It is the primary ' ...
and
iron metabolism
Human iron metabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level. Iron is both necessary to the body and potentially toxic. Controlling iron levels in the body is a critically impo ...
more broadly, of
chloroplast structure, and of the
biosynthesis of
heme
Heme, or haem (pronounced / hi:m/ ), is a precursor to hemoglobin, which is necessary to bind oxygen in the bloodstream. Heme is biosynthesized in both the bone marrow and the liver.
In biochemical terms, heme is a coordination complex "consis ...
and related molecules.
Granick was born in
New York City
New York, often called New York City or NYC, is the most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the most densely populated major city in the Un ...
, and earned a B.S. (1931), M.S. (1933) and Ph.D. (1938) degrees from the
University of Michigan
, mottoeng = "Arts, Knowledge, Truth"
, former_names = Catholepistemiad, or University of Michigania (1817–1821)
, budget = $10.3 billion (2021)
, endowment = $17 billion (2021)As o ...
, where he completed a dissertation in
plant physiology. In 1939 Granick joined the laboratory of biochemist
Leonor Michaelis
Leonor Michaelis (16 January 1875 – 8 October 1949) was a German biochemist, physical chemist, and physician, known for his work with Maud Menten on enzyme kinetics in 1913, as well as for work on enzyme inhibition, pH and quinones.
E ...
at the
Rockefeller Institute for Medical Research
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classi ...
; he would remain at the Rockefeller Institute for the rest of his scientific career.
[Attallah Kappas and Richard D. Levere,]
In memoriam: Sam Granick 1909-1977
, ''Blood'', volume 50, number 3, September 1977, p. 543. Between 1942 and 1946, Granick and Michaelis, along with Alexandre Rothen, published a series of important research papers on ferritin and other ferric compounds in the ''
Journal of Biological Chemistry''. In the first paper, Granick showed that—contrary to earlier studies—purified ferritin contains no
nucleic acid and varies in its content of iron and phosphorus. A second paper, by Granick and Michaelis, showed that iron could be removed from ferritin to produce
apoferritin. Granick went on to study the structure of chloroplasts, including, in 1947 with
Keith R. Porter, the first application of an
electron microscope
An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a hi ...
to chloroplasts.
Granick was a member of the
United States National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
and the
American Academy of Arts and Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...
.
Notes and references
{{DEFAULTSORT:Grannick, Sam
American biochemists
1909 births
1977 deaths
Rockefeller University people
Members of the United States National Academy of Sciences
University of Michigan alumni