organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The ...
isolated from
saffron
Saffron () is a spice derived from the flower of ''Crocus sativus'', commonly known as the "saffron crocus". The vivid crimson stigma and styles, called threads, are collected and dried for use mainly as a seasoning and colouring agent i ...
crocus
''Crocus'' (; plural: crocuses or croci) is a genus of seasonal flowering plants in the family Iridaceae (iris family) comprising about 100 species of perennials growing from corms. They are low growing plants, whose flower stems remain undergro ...
flowers (''Crocus sativus''). It is the constituent primarily responsible for the aroma of saffron.
It is believed that safranal is a degradation product of the
carotenoid
Carotenoids (), also called tetraterpenoids, are yellow, orange, and red organic compound, organic pigments that are produced by plants and algae, as well as several bacteria, and Fungus, fungi. Carotenoids give the characteristic color to pumpki ...
zeaxanthin
Zeaxanthin is one of the most common carotenoids in nature, and is used in the xanthophyll cycle. Synthesized in plants and some micro-organisms, it is the pigment that gives paprika (made from bell peppers), corn, saffron, goji ( wolfberries), ...
via the intermediate
picrocrocin
Picrocrocin is a monoterpene glycoside precursor of safranal. It is found in the spice saffron, which comes from the crocus flower. Picrocrocin has a bitter taste, and is the chemical most responsible for the taste of saffron.
During the drying ...
.
Pharmacology
Safranal is an effective anticonvulsant in animal models, shown to act as an
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
antioxidant
Antioxidants are compounds that inhibit oxidation, a chemical reaction that can produce free radicals. This can lead to polymerization and other chain reactions. They are frequently added to industrial products, such as fuels and lubricant ...
and free radical scavenging activity, along with
cytotoxicity
Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (''Bitis arietans'') or brown recluse spider (''Loxosceles reclusa'').
Cell physiology
Treating cells ...
towards cancer cells
in vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...
. One of its anticancer mechanisms of action involves disruption of the normal assembly dynamics of cellular microtubules. It has also been shown to have antidepressant properties in animals and pilot studies in humans.
Natural sources
Natural sources of safranal include:
*''
Microcystis
''Microcystis'' is a genus of freshwater cyanobacteria that includes the harmful algal bloom-forming ''Microcystis aeruginosa''. Many members of a ''Microcystis'' community can produce neurotoxins and hepatotoxins, such as microcystin and cyanop ...
'' (cyanobacterium)
*''
Aspalathus linearis
Rooibos ( ; , meaning "red bush"), or ''Aspalathus linearis'', is a broom-like member of the plant family Fabaceae that grows in South Africa's fynbos biome.
The leaves are used to make a herbal tea that is called rooibos (especially in ...
'' (Rooibos)
*''
Camellia sinensis
''Camellia sinensis'' is a species of evergreen shrub or small tree in the flowering plant family Theaceae. Its leaves and leaf buds are used to produce the popular beverage, tea. Common names include tea plant, tea shrub, and tea tree (not to ...
'' (Tea leaf)
*''
Crocus sativus
''Crocus sativus'', commonly known as saffron crocus or autumn crocus, is a species of flowering plant in the iris family (biology), family Iridaceae. A cormous autumn-flowering cultivated perennial plant, perennial, unknown in the wild, it is ...
'' (Saffron)
*''
Ficus carica
The fig is the edible fruit of ''Ficus carica'', a species of small tree in the flowering plant family Moraceae. Native to the Mediterranean and western Asia, it has been cultivated since ancient times and is now widely grown throughout the world ...
'' (Fig leaf)
*''
Lycium chinense
''Lycium chinense'' is one of two species of boxthorn shrub in the family Solanaceae. Along with ''Lycium barbarum'', it produces the goji berry ("wolfberry"). Two varieties are recognized, ''L. chinense'' var. ''chinense'' and ''L. chinense'' ...
Centaurea sibthorpii
''Centaurea'' () is a genus of over 700 species of herbaceous thistle-like flowering plants in the family Asteraceae. Members of the genus are found only north of the equator, mostly in the Eastern Hemisphere; the Middle East and surrounding re ...
''
*''
Centaurea amanicola
''Centaurea'' () is a genus of over 700 species of herbaceous thistle-like flowering plants in the family Asteraceae. Members of the genus are found only north of the equator, mostly in the Eastern Hemisphere; the Middle East and surrounding re ...
''
*''
Centaurea consanguinea
''Centaurea'' () is a genus of over 700 species of herbaceous thistle-like flowering plants in the family Asteraceae. Members of the genus are found only north of the equator, mostly in the Eastern Hemisphere; the Middle East and surrounding re ...
''
*''
Erodium cicutarium
''Erodium cicutarium'', also known as common stork's-bill, redstem filaree, redstem stork's bill or pinweed, is a herbaceous annual plant, annual – or in warm climates, biennial plant, biennial – member of the family Geraniaceae of flowering ...
'' (common stork's-bill or pinweed)
*''
Calycopteris floribunda
''Getonia'' is a monotypic genus of flowering plants belonging to the family Combretaceae. Its native range is India, Assam to Peninsula Malaysia.
Getonia floribunda
''Getonia floribunda'', commonly known as ukshi, is a large climbing shrub wh ...
'' (Ukshi)
*''
Sambucus nigra
''Sambucus nigra'' is a species complex of flowering plants in the family Adoxaceae native to most of Europe. Common names include elder, elderberry, black elder, European elder, European elderberry, European black elderberry and tramman (Isle ...
'' (elderberry)
*''
Citrus limon
The lemon (''Citrus limon'') is a species of small evergreen trees in the flowering plant family Rutaceae, native to Asia, primarily Northeast India (Assam), Northern Myanmar or China.
The tree's ellipsoidal yellow fruit is used for culin ...