Soluble tumor necrosis factor receptors (sTNFR) are the cleaved-off extracellular domains of
transmembrane TNF receptors. They are proposed to enter the bloodstream either via shedding by the enzyme
TACE or through exocytosis of the full-length receptor in exosome-like vesicles. Elevated levels of sTNFR are seen in inflammatory processes such as
infection
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dis ...
,
malignancy
Malignancy () is the tendency of a medical condition to become progressively worse.
Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous ''benign'' tumor in that a malignancy is not s ...
and
autoimmune diseases.
References
{{Cytokine receptor modulators
Clusters of differentiation
TNF receptor family