ST-1936 (2-methyl-5-chloro-''N'',''N''-dimethyltryptamine) is a
tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...
derivative which is used in
scientific research
The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific m ...
. It acts as a
selective 5-HT6 receptor agonist, with a
Ki of 13 nM, and much weaker action at
5-HT2B and
5-HT7 subtypes. In animal studies it has been found to increase
dopamine and
noradrenaline
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin '' ad'', ...
mediated signalling but decreases
glutamatergic
Glutamatergic means "related to glutamate". A glutamatergic agent (or drug) is a chemical that directly modulates the excitatory amino acid (glutamate/aspartate) system in the body or brain. Examples include excitatory amino acid receptor agonis ...
transmission, and has
antidepressant effects.
See also
*
EMD-386,088
EMD-386088 is an indole derivative which is used in scientific research. It acts as a potent 5-HT6 receptor partial agonist, with a Ki of 1 nM, a significantly higher affinity than older 5-HT6 agonists such as EMDT, although it possesses moder ...
*
EMDT
2-Ethyl-5-methoxy-''N'',''N''-dimethyltryptamine (EMDT) is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 16 nM, and was one of the first selective agonists developed ...
*
5-Bromo-DMT
5-Bromo-DMT (5-bromo-''N'',''N''-dimethyltryptamine) is a psychedelic brominated indole alkaloid found in the sponges '' Smenospongia aurea'' and '' Smenospongia echina'', as well as in '' Verongula rigida'' (0.00142% dry weight) alongside 5,6-D ...
*
5-Chloro-AMT
References
{{Tryptamines
5-HT6 agonists
Tryptamines
Chloroarenes