Succinic semialdehyde (SSA) is a
GABA metabolite. It is formed from GABA by the action of
GABA transaminase
In enzymology, 4-aminobutyrate transaminase (), also called GABA transaminase or 4-aminobutyrate aminotransferase, or GABA-T, is an enzyme that catalyzes the chemical reaction:
:4-aminobutanoate + 2-oxoglutarate \rightleftharpoons succinate sem ...
and further
oxidised to become
succinic acid, which enters
TCA cycle
The citric acid cycle (CAC)—also known as the Krebs cycle or the TCA cycle (tricarboxylic acid cycle)—is a series of chemical reactions to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins ...
.
See also
*
Succinic semialdehyde dehydrogenase deficiency
Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare autosomal recessive disorder of the degradation pathway of the inhibitory neurotransmitter γ-aminobutyric acid, or GABA. The disorder has been identified in approximately 350 fa ...
*
4-aminobutyrate aminotransferase
In enzymology, 4-aminobutyrate transaminase (), also called GABA transaminase or 4-aminobutyrate aminotransferase, or GABA-T, is an enzyme that catalyzes the chemical reaction:
:4-aminobutanoate + 2-oxoglutarate \rightleftharpoons succinate semi ...
References
Aldehydes
Carboxylic acids
Gamma-Hydroxybutyric acid
Aldehydic acids
{{biochem-stub