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SPINA-GBeta is a calculated biomarker for pancreatic beta cell function.insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...
that beta cells can produce per time-unit (e.g. in one second).


How to determine GBeta

The index is derived from a mathematical model of insulin-glucose homeostasis. For diagnostic purposes, it is calculated from fasting
insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...
and glucose concentrations with: _=\frac.'I''∞): Fasting Insulin plasma concentration (μU/mL)
'G''∞): Fasting blood glucose concentration (mg/dL)
''D''''β'': EC50 for glucose at beta cells (7 mmol/L)
''G''3: Parameter for
pharmacokinetics Pharmacokinetics (from Ancient Greek ''pharmakon'' "drug" and ''kinetikos'' "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered ...
(58,8 s/L)


Validity

SPINA-GBeta significantly correlates with the M value in glucose clamp studies and (better than HOMA-Beta) with the two-hour value in oral glucose tolerance testing (OGTT), glucose rise in OGTT, subscapular skinfold, truncal fat content and the HbA1c fraction.


See also

* SPINA-GR * SPINA-GD *
SPINA-GT Thyroid's secretory capacity (''GT'', also referred to as thyroid's incretory capacity, maximum thyroid hormone output, T4 output or, if calculated from serum levels of thyrotropin and thyroxine, as SPINA-GT) is the maximum stimulated amount of thy ...
* Homeostatic model assessment * QUICKI


Notes


References


External links


Functions for R and S for calculating SPINA-GBeta and SPINA-GR(Permanent DOI)
{{Authority control Diabetes Endocrinology Human homeostasis Endocrine procedures Static endocrine function tests