Anion exchange protein 2 (AE2) is a
membrane transport protein
A membrane transport protein (or simply transporter) is a membrane protein involved in the movement of ions, small molecules, and macromolecules, such as another protein, across a biological membrane. Transport proteins are integral transmembra ...
that in humans is encoded by the ''SLC4A2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
AE2 is functionally similar to the
Band 3
Band 3 anion transport protein, also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1), is a protein that is encoded by the gene in humans.
Band 3 anion transport protein is a phylogenetically-preserved ...
Cl−/
HCO3− exchange
Exchange may refer to:
Physics
*Gas exchange is the movement of oxygen and carbon dioxide molecules from a region of higher concentration to a region of lower concentration. Places United States
* Exchange, Indiana, an unincorporated community
* ...
protein.
Mice have been used to explore the function of AE2. AE2 contributes to
basolateral membrane Epithelial polarity is one example of the cell polarity that is a fundamental feature of many types of cells. Epithelial cells feature distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via t ...
HCO
3− transport in the
gastrointestinal tract.
AE2 is required for
spermiogenesis
Spermiogenesis is the final stage of spermatogenesis, during which the spermatids develop into mature spermatozoon, spermatozoa. At the beginning of the stage, the spermatid is a more or less circular cell containing a cell nucleus, nucleus, Golg ...
in mice.
AE2 is required for normal
osteoclast
An osteoclast () is a type of bone cell that breaks down bone tissue. This function is critical in the maintenance, repair, and remodeling of bones of the vertebral skeleton. The osteoclast disassembles and digests the composite of hydrated pro ...
function.
The activity of AE2 is sensitive to
pH.
AE3 has been suggested as a target for prevention of
diabetic vasculopathy.
See also
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Solute carrier family
References
Further reading
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Solute carrier family
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