Sialic acid-binding Ig-like lectin 10 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''SIGLEC10''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Siglec-G is often referred to as the murine paralog of human Siglec-10
Structure and function
Like most but not all other Siglecs, Siglec-10 bears an ITIM (
Immunoreceptor tyrosine-based inhibitory motif An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly in the cytoplasmic domains of many inhibitory receptors of the non-catalytic tyrosine-phosphorylated receptor family fou ...
) within its cytoplasmic domain. Siglec-10 is a ligand for
CD52
CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the ''CD52'' gene.
CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocyt ...
, the target of the therapeutic monoclonal antibody
Alemtuzumab
Alemtuzumab, sold under the brand names Campath and Lemtrada among others, is a medication used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis. In CLL, it has been used as both a first line and second line treatment. In MS it ...
.
It is also reported to bind to
Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule
CD24 also known as HSA (Heat-stable antigen).
Gene family summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
upplied by OMIMref name="entrez" />
References
Further reading
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SIGLEC