SHC014-CoV is a

SARS Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1), the first identified strain of the SARS coronavirus species, ''sever ...

-like

coronavirus Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the com ...

(SL-COV) which infects

horseshoe bats A horseshoe is a fabricated product designed to protect a horse hoof from wear. Shoes are attached on the palmar surface (ground side) of the hooves, usually nailed through the insensitive hoof wall that is anatomically akin to the human toen ...

(family Rhinolophidae). It was discovered in

Kunming Kunming (; ), also known as Yunnan-Fu, is the capital and largest city of Yunnan province, China. It is the political, economic, communications and cultural centre of the province as well as the seat of the provincial government. The headquar ...

Yunnan Province Yunnan , () is a landlocked province in the southwest of the People's Republic of China. The province spans approximately and has a population of 48.3 million (as of 2018). The capital of the province is Kunming. The province borders the C ...

, China. It was discovered along with SL-CoV Rs3367, which was the first bat SARS-like coronavirus shown to directly infect a human cell line. The line of Rs3367 that infected human cells was named

Bat SARS-like coronavirus WIV1 Bat SARS-like coronavirus WIV1 (Bat SL-CoV-WIV1), also sometimes called SARS-like coronavirus WIV1, is a strain of '' severe acute respiratory syndrome–related coronavirus'' (SARSr-CoV) isolated from Chinese rufous horseshoe bats in 2013 ('' Rh ...

Discovery

From April 2011 to September 2012, researchers from the

Wuhan Institute of Virology The Wuhan Institute of Virology, Chinese Academy of Sciences (WIV; ) is a research institute on virology administered by the Chinese Academy of Sciences (CAS), which reports to the State Council of the People's Republic of China. The institute ...

collected 117 anal swabs and fecal samples of bats from a

Chinese rufous horseshoe bat The Chinese rufous horseshoe bat (''Rhinolophus sinicus'') is a species of bat in the family Rhinolophidae. It is found in Bhutan, China, India, Nepal, and Vietnam. The species is most easily confused with '' R. affinis'', from which it is bes ...

s (''Rhinolophus sinicus'') colony in Kunming City (Yunnan Province in south-western China). 27 out of 117 samples (23%) contained seven different isolates of SARS-like coronaviruses, among which were two previously unknown, called RsSHC014 and Rs3367.

Virology

In 2013, bat SARS-like coronavirus Rs3367 was shown to be able to directly infect the human HeLa cell line. It was the first time that human cells had been infected with a bat SARS-like coronavirus in the lab. The strain of Rs3367 that infected the human cells was named “Bat SARS-like coronavirus WIV”. In 2015, the

University of North Carolina at Chapel Hill A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States ...

and the Wuhan Institute of Virology conducted research showing that SHC014 could be made to infect the human HeLa cell line, through the use of

reverse genetics Reverse genetics is a method in molecular genetics that is used to help understand the function(s) of a gene by analysing the phenotypic effects caused by genetically engineering specific nucleic acid sequences within the gene. The process proce ...

to create a chimeric virus consisting of a surface protein of SHC014 and the backbone of a SARS coronavirus. The SL-SHC014-MA15 version of the virus, primarily engineered to infect mice, has been shown to differ by over 5,000 nucleotides from

SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the ongoing COVID-19 pandemic. The virus previously had a ...

, the cause of the

COVID-19 pandemic The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel virus was first identif ...

Phylogenetic

References

* {{Coronaviridae Bat virome 2013 in China 2013 in biology 2015 in biology SARS-related coronavirus Infraspecific virus taxa

Discovery

Virology

Phylogenetic

See also

References

References