SH-I-048A (SH-i-048A) is a
benzodiazepine derivative related in structure to compounds such as
flubromazepam and
meclonazepam. SH-I-048A is described as a non subtype selective
superagonist at the benzodiazepine site of
GABAA receptors,
with a
binding affinity
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a m ...
of 0.77nM at the α
1 subtype, 0.17nM at α
2, 0.38nM at α
3 and 0.11nM at α
5.
It has been used to study the functional differences between the different subtypes of the GABA
A receptor.
See also
*
GL-II-73
GL-II-73 (GL-ii-073) is a benzodiazepine derivative related in chemical structure to compounds such as midazolam and adinazolam. It is described as an α5 preferring positive allosteric modulator of the benzodiazepine site of GABAA receptors, w ...
*
QH-II-66
QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation a ...
*
SH-053-R-CH3-2'F
References
{{GABAAR PAMs
Benzodiazepines
GABAA receptor positive allosteric modulators