Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
encoding an
SR protein
SR proteins are a conserved family of proteins involved in RNA splicing. SR proteins are named because they contain a protein domain with long repeats of serine and arginine amino acid residue (chemistry), residues, whose Amino acid#Table of stand ...
involved in splice site selection in
alternative splicing
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be ...
.
Interactions
SFRS9 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
Y box binding protein 1
Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the ''YBX1'' gene.
Clinical significance
YBX1 is a potential drug target in cancer thera ...
and
NOL3
Nucleolar protein 3 is a protein that in humans is encoded by the ''NOL3'' gene.
Nol3 has been shown to be induced in multiple cancer types and acts as a repressor of apoptosis leading to resistance and proliferation. Paradoxically, loss of Nol3 ...
.
References
Further reading
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