Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
encoded by the ''SFN''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
in humans.
The protein is named for its presence in stratified
epithelial cells
Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellula ...
.
Interactions
Stratifin has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
PLK4
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the ''PLK4'' gene. The Drosophila homolog is SAK, the C elegans homolog is zyg-1, and the Xenopus homolog is Plx4.
Function
''PLK4' ...
,
ERRFI1
ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ''ERRFI1'' gene.
MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein ...
,
MARK3
MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the ''MARK3'' gene.
Interactions
MARK3 has been shown to interact with Stratifin
Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a p ...
,
[ JUB][ and ]YWHAG
14-3-3 protein gamma is a protein that in humans is encoded by the ''YWHAG'' gene.
This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved pro ...
.[
]
References
Further reading
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{{gene-1-stub
14-3-3 proteins