Sodium channel protein type 7 subunit alpha is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''SCN7A''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
on the chromosome specifically located at 2q21-23 chromosome site.
This is one of 10 Sodium channel types, and is expressed in the heart, the uterus and in glial cells. Its sequence identity is 48, and it is the only sodium channel known to be completely un-blockable by
tetrodotoxin
Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the toxin. Although tetrodotoxin was discovered ...
(TTX).
See also
*
Sodium channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels and can be classified according to the trigger that opens the channel ...
Scn7a is the name of the gene that encodes to a membrane protein, in particular a Sodium Channel Na
x (also known as NaG, Na
v2.1, etc.) It belongs to the family of voltage-gated sodium channels, though is not activated by changes in the membrane's voltage unlike other members in the family, namely (Na
v1.1 to Na
v1.9); it activates by changes in the extracellular concentration of sodium
150 mM
Fifteen or 15 may refer to:
*15 (number), the natural number following 14 and preceding 16
*one of the years 15 BC, AD 15, 1915, 2015
Music
*Fifteen (band), a punk rock band
Albums
* ''15'' (Buckcherry album), 2005
* ''15'' (Ani Lorak album ...
References
Further reading
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External links
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{{Ion channels, g2
Sodium channels