SCG2, also called secretogranin II (chromogranin C), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
which in humans is encoded by the ''SCG2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
The protein encoded by this gene is a member of the
chromogranin
Granin (chromogranin and secretogranin) is a protein family of regulated secretory proteins ubiquitously found in the cores of amine and peptide hormone and neurotransmitter dense-core secretory vesicles.
Function
Granins (chromogranins or sec ...
/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide
secretoneurin Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC).
It is cleaved into the following 3 chains:
# PE-11
# GAWK peptide
# CCB peptide
Function
Secretoneurin is involved in chemotaxis of monocytes ...
, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.
See also
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Chromogranin
Granin (chromogranin and secretogranin) is a protein family of regulated secretory proteins ubiquitously found in the cores of amine and peptide hormone and neurotransmitter dense-core secretory vesicles.
Function
Granins (chromogranins or sec ...
Further reading
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References
{{gene-2-stub