Histone deacetylase complex subunit SAP18 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''SAP18''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.
Additionally, SAP18s splice variants are implicated in apoptotic cycles.
Interactions
SAP18 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
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POLE2
DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the ''POLE2'' gene.
Interactions
POLE2 has been shown to interact with SAP18
Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the ''SAP1 ...
,
and
*
RGS10
Regulator of G-protein signaling 10 is a protein that in humans is encoded by the ''RGS10'' gene.
Function
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha ...
.
References
Further reading
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External links
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