HOME

TheInfoList



OR:

Ruslan Maksutovich Medzhitov (born March 12, 1966) is a professor of immunobiology at
Yale School of Medicine The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. The primary te ...
, a member of
Yale Cancer Center Yale Cancer Center (YCC) was founded in 1974 as a result of an act of Congress in 1971, which declared the nation's "war on cancer". It is one of a network of 51 Comprehensive Cancer Centers designated by the National Cancer Institute (NCI).Cur ...
, and a
Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fi ...
investigator. His research focuses on the analysis of the innate immune system, inflammatory response, innate control of the adaptive immunity, and host-pathogen interactions. On April 27, 2010, he was elected to the US National Academy of Sciences.


Biography

Ruslan Medzhitov was born in 1966 in
Tashkent Tashkent (, uz, Toshkent, Тошкент/, ) (from russian: Ташкент), or Toshkent (; ), also historically known as Chach is the capital and largest city of Uzbekistan. It is the most populous city in Central Asia, with a population of 2 ...
. He earned a
Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University o ...
at
Tashkent State University National University of Uzbekistan (NUUz) () is a public university located in Tashkent, Uzbekistan. NUUz is the oldest and largest university in Uzbekistan. National University of Uzbekistan is named after Mirzo Ulugbek. NUUz professors and tea ...
before going on to pursue a PhD in biochemistry at
Moscow State University M. V. Lomonosov Moscow State University (MSU; russian: Московский государственный университет имени М. В. Ломоносова) is a public research university in Moscow, Russia and the most prestigious ...
. In 1992 he read an article by
Charles Janeway Charles Alderson Janeway, Jr. (1943–2003) was a noted immunologist who helped create the modern field of innate immunity. A member of the National Academy of Sciences, he held a faculty position at Yale University's Medical School and was a ...
about a hypothetical flip-flop triggered
innate immunity The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an older evolutionary defense strategy, relatively speaking, and is the ...
. Before coming to Yale, he was a fellow in the laboratory of
Russell Doolittle Russell F. Doolittle (January 10, 1931 – October 11, 2019) was an American biochemist who taught at the University of California, San Diego (UCSD). Described as a "world-renowned evolutionary biologist", Doolittle's research primarily focused ...
at the University of California in San Diego. A graduate student with no special immunological training, he realized that it was necessary to find pattern-recognizing receptors and was determined to do so. He wrote to Janeway about his desire to work on this topic, but he did not immediately accept him into his laboratory. He did his post-doctoral training with
Charles Janeway Charles Alderson Janeway, Jr. (1943–2003) was a noted immunologist who helped create the modern field of innate immunity. A member of the National Academy of Sciences, he held a faculty position at Yale University's Medical School and was a ...
at Yale University School of Medicine from 1994 to 1999. In 1997, Medzhitov and Janeway proved that humans have a
Toll-like receptor Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize ...
(later named
TLR4 Toll-like receptor 4 is a protein that in humans is encoded by the ''TLR4'' gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an ...
), which activates genes necessary for the
immune response An immune response is a reaction which occurs within an organism for the purpose of defending against foreign invaders. These invaders include a wide variety of different microorganisms including viruses, bacteria, parasites, and fungi which coul ...
. In 2000, Medzhitov was selected as a Searle Scholar. On April 27, 2010, he was elected to the US National Academy of Sciences and became one of the youngest academicians. In 2011, the Russian edition of ''
Forbes ''Forbes'' () is an American business magazine owned by Integrated Whale Media Investments and the Forbes family. Published eight times a year, it features articles on finance, industry, investing, and marketing topics. ''Forbes'' also r ...
'' published a list of 50 Russians who “conquered the world”. It includes scientists, businessmen, cultural and sports figures who have integrated into the world community and have achieved success outside of Russia. Medzhitov was included in this Forbes list of 10 famous scientists of Russian origin. On May 15, 2012, Medzhitov was awarded a diploma and a medal of the Honorary Professor at
Moscow State University M. V. Lomonosov Moscow State University (MSU; russian: Московский государственный университет имени М. В. Ломоносова) is a public research university in Moscow, Russia and the most prestigious ...
, where he regularly reads his lectures. Currently, he serves as a
Sterling professor Sterling Professor, the highest academic rank at Yale University, is awarded to a tenured faculty member considered the best in his or her field. It is akin to the rank of university professor at other universities. The appointment, made by the ...
at the
Yale University School of Medicine The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. The primary te ...
.


Awards

He has received the William Coley Award for Distinguished Research in Basic and Tumor Immunology from the Cancer Research Institute, a Master of Arts Privatum at
Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the w ...
, the Emil von Behring Award, AAI-BD Biosciences Investigator Award, a doctorate ''honoris Causa'' at the
University of Munich The Ludwig Maximilian University of Munich (simply University of Munich or LMU; german: Ludwig-Maximilians-Universität München) is a public research university in Munich, Germany. It is Germany's sixth-oldest university in continuous operatio ...
, the Blavatnik Award for Young Scientists from the New York Academy of Arts and Sciences, the Howard Taylor Ricketts Award from the University of Chicago, the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research in 2010, and the
Dickson Prize The Dickson Prize in Medicine and the Dickson Prize in Science were both established in 1969 by Joseph Z. Dickson and Agnes Fischer Dickson. Dickson Prize in Medicine The Dickson Prize in Medicine is awarded annually by the University of Pittsburg ...
in 2019. In recognition of his prolific contributions to the field of immunological research, he was elected to the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...
and in 2011 he was a co-recipient of the
Shaw Prize The Shaw Prize is an annual award presented by the Shaw Prize Foundation. Established in 2002 in Hong Kong, it honours "individuals who are currently active in their respective fields and who have recently achieved distinguished and signifi ...
in Life Science and Medicine. In 2013, Medzhitov received the Vilcek Prize in Biomedical Science.


Personal life

In 2007, Medzhitov married Akiko Iwasaki, a professor in the Department of Molecular, Cellular, and Developmental Biology at
Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the w ...
. They have two daughters.


References


External links


HHMI Scientist Bio: Ruslan MedzhitovBio at Yale University
{{DEFAULTSORT:Medzhitov, Ruslan 1966 births Living people Yale School of Medicine faculty Yale Sterling Professors Members of the United States National Academy of Sciences Howard Hughes Medical Investigators Scientists from Tashkent Members of the National Academy of Medicine Foreign Members of the Russian Academy of Sciences