Robert W. McCarley, MD, (1937–2017) was Chair and Professor of Psychiatry at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is cons ...

and the VA Boston Healthcare System. He is also Director of the Laboratory of Neuroscience located at the Brockton VA Medical Center and the

McLean Hospital McLean Hospital () (formerly known as Somerville Asylum and Charlestown Asylum) is a psychiatric hospital in Belmont, Massachusetts. It is noted for its clinical staff expertise and neuroscience research and is also known for the large number of ...

. McClarley was a prominent researcher in the field of

sleep Sleep is a sedentary state of mind and body. It is characterized by altered consciousness, relatively inhibited Perception, sensory activity, reduced muscle activity and reduced interactions with surroundings. It is distinguished from wakefuln ...

and

dream A dream is a succession of images, ideas, emotions, and sensations that usually occur involuntarily in the mind during certain stages of sleep. Humans spend about two hours dreaming per night, and each dream lasts around 5 to 20 minutes, althou ...

ing as well as

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social w ...

. McCarley graduated from

Harvard College Harvard College is the undergraduate college of Harvard University, an Ivy League research university in Cambridge, Massachusetts. Founded in 1636, Harvard College is the original school of Harvard University, the oldest institution of higher ...

in 1959 and Harvard Medical School in 1964. During his residency at Massachusetts Mental Health Center, he studied with J. Allan Hobson. In 1977, Hobson and McCarley developed the activation synthesis theory of dreaming that said that dreams do not have meanings and are the result of the brain attempting to make sense of random neuronal firing in the cortex. McCarley has extensively studied the

brainstem The brainstem (or brain stem) is the posterior stalk-like part of the brain that connects the cerebrum with the spinal cord. In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata. The midbrain is ...

mechanisms that control

REM sleep Rapid eye movement sleep (REM sleep or REMS) is a unique phase of sleep in mammals and birds, characterized by random rapid movement of the eyes, accompanied by low muscle tone throughout the body, and the propensity of the sleeper to dream ...

. Additionally, he has studied the buildup of

adenosine Adenosine (symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9- glycosidic bond. Adenosine is one of the four nucleoside building ...

in the

basal forebrain Part of the human brain, the basal forebrain structures are located in the forebrain to the front of and below the striatum. They include the ventral basal ganglia (including nucleus accumbens and ventral pallidum), nucleus basalis, diagonal b ...

following

sleep deprivation Sleep deprivation, also known as sleep insufficiency or sleeplessness, is the condition of not having adequate duration and/or quality of sleep to support decent alertness, performance, and health. It can be either chronic or acute and may vary ...

. In the area of schizophrenia, McCarley has studied brain abnormalities in patients with schizophrenia. McCarley and Martha Shenton published a classic paper in 1992 that described a relationship in a reduction in the volume of the left

superior temporal gyrus The superior temporal gyrus (STG) is one of three (sometimes two) gyri in the temporal lobe of the human brain, which is located laterally to the head, situated somewhat above the external ear. The superior temporal gyrus is bounded by: * the l ...

and

thought disorder A thought disorder (TD) is any disturbance in cognition that adversely affects language and thought content, and thereby communication. A variety of thought disorders were said to be characteristic of people with schizophrenia. A content-though ...

in patients with schizophrenia. McCarley has been presented with many awards for his research. In 1998, he received William S. Middleton Award which is the highest honor awarded to a VA biomedical research scientist. He has also been presented awards from the

Sleep Research Society The Sleep Research Society (SRS) is an organization that promotes the science of sleep and related disorders. Additionally, the SRS is dedicated to the training and education of future sleep researchers. Organization The organization traces its ...

American Psychiatric Association The American Psychiatric Association (APA) is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the largest psychiatric organization in the world. It has more than 37,000 members are invo ...

, and

American Academy of Sleep Medicine The American Academy of Sleep Medicine (AASM) is a United States professional society for the medical subspecialty of sleep medicine which includes disorders of circadian rhythms. It was established in 1975. The organization's functions include ...

. In 2007, McCarley was ranked as the ninth most cited author in the field of schizophrenia research over the past decade. McCarley has published around 300 research articles and several books and book chapters such as ''Brain Control of Wakefulness and Sleep''.Steriade MM and McCarley RW. Brain Control of Wakefulness and Sleep. Springer; 2nd ed. edition, 2005.

References

External links

An ESSAY with Dr. Robert McCarleyFaculty Profile
Harvard Medical School {{DEFAULTSORT:McCarley, Robert American psychiatrists Sleep researchers Harvard Medical School faculty Harvard Medical School alumni 2017 deaths 1937 births People from Mayfield, Kentucky Harvard College alumni McLean Hospital physicians