Renal compensation is a mechanism by which the

kidneys The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; bloo ...

can regulate the plasma pH. It is slower than respiratory compensation, but has a greater ability to restore normal values. In

respiratory acidosis Respiratory acidosis is a state in which decreased ventilation ( hypoventilation) increases the concentration of carbon dioxide in the blood and decreases the blood's pH (a condition generally called acidosis). Carbon dioxide is produced contin ...

, the kidney produces and excretes

ammonium The ammonium cation is a positively-charged polyatomic ion with the chemical formula or . It is formed by the protonation of ammonia (). Ammonium is also a general name for positively charged or protonated substituted amines and quaterna ...

(NH₄⁺) and monophosphate, generating

bicarbonate In inorganic chemistry, bicarbonate (IUPAC-recommended nomenclature: hydrogencarbonate) is an intermediate form in the deprotonation of carbonic acid. It is a polyatomic anion with the chemical formula . Bicarbonate serves a crucial biochemi ...

in the process while clearing acid. In

respiratory alkalosis Respiratory alkalosis is a medical condition in which increased respiration elevates the blood pH beyond the normal range (7.35–7.45) with a concurrent reduction in arterial levels of carbon dioxide. This condition is one of the four primary dis ...

, less

(HCO₃⁻) is reabsorbed, thus lowering the pH.

References

{{Renal physiology Acid–base disturbances