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Raymond Urgel Lemieux, CC, AOE, FRS (June 16, 1920 – July 22, 2000) was a
Canadian Canadians (french: Canadiens) are people identified with the country of Canada. This connection may be residential, legal, historical or cultural. For most Canadians, many (or all) of these connections exist and are collectively the source of ...
organic chemist Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J. ...
, who pioneered many discoveries in the field of
chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a natural science that covers the elements that make up matter to the compounds made of atoms, molecules and ions: their composition, structure, proper ...
, his first and most famous being the
synthesis Synthesis or synthesize may refer to: Science Chemistry and biochemistry * Chemical synthesis, the execution of chemical reactions to form a more complex molecule from chemical precursors **Organic synthesis, the chemical synthesis of organ ...
of
sucrose Sucrose, a disaccharide, is a sugar composed of glucose and fructose subunits. It is produced naturally in plants and is the main constituent of white sugar. It has the molecular formula . For human consumption, sucrose is extracted and refine ...
. His contributions include the discovery of the
anomeric effect In organic chemistry, the anomeric effect or Edward-Lemieux effect is a stereoelectronic effect that describes the tendency of heteroatomic substituents adjacent to a heteroatom within a cyclohexane ring to prefer the ''axial'' orientation instea ...
and the development of general methodologies for the synthesis of saccharides still employed in the area of
carbohydrate chemistry Carbohydrate chemistry is a subdiscipline of chemistry primarily concerned with the detection, synthesis, structure, and function of carbohydrates. Due to the general structure of carbohydrates, their synthesis is often preoccupied with the sele ...
. He was a fellow of the
Royal Society of Canada The Royal Society of Canada (RSC; french: Société royale du Canada, SRC), also known as the Academies of Arts, Humanities and Sciences of Canada (French: ''Académies des arts, des lettres et des sciences du Canada''), is the senior national, bil ...
and the
Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
(England), and a recipient of the prestigious Albert Einstein World Award of Science and
Wolf Prize The Wolf Prize is an international award granted in Israel, that has been presented most years since 1978 to living scientists and artists for ''"achievements in the interest of mankind and friendly relations among people ... irrespective of nati ...
in Chemistry.


Life and career

''Dr. Raymond U. Lemieux'' was born in
Lac La Biche, Alberta Lac La Biche ( ) is a hamlet in Lac La Biche County within northeast Alberta, Canada. It is located approximately northeast of the provincial capital of Edmonton. Previously incorporated as a town, Lac La Biche amalgamated with Lakeland Count ...
, Canada. His family moved to
Edmonton Edmonton ( ) is the capital city of the Canadian province of Alberta. Edmonton is situated on the North Saskatchewan River and is the centre of the Edmonton Metropolitan Region, which is surrounded by Alberta's central region. The city an ...
,
Alberta Alberta ( ) is one of the thirteen provinces and territories of Canada. It is part of Western Canada and is one of the three prairie provinces. Alberta is bordered by British Columbia to the west, Saskatchewan to the east, the Northwest T ...
in 1926. He studied chemistry at the
University of Alberta The University of Alberta, also known as U of A or UAlberta, is a Public university, public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexande ...
and received a BSc with Honours in Chemistry in 1943. He went on to study at
McGill University McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec, Canada. Founded in 1821 by royal charter granted by King George IV,Frost, Stanley Brice. ''McGill Univer ...
, where he received his PhD in
Organic Chemistry Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J ...
in 1946. He won a post-doctoral
scholarship A scholarship is a form of financial aid awarded to students for further education. Generally, scholarships are awarded based on a set of criteria such as academic merit, diversity and inclusion, athletic skill, and financial need. Scholars ...
at
Ohio State University The Ohio State University, commonly called Ohio State or OSU, is a public land-grant research university in Columbus, Ohio. A member of the University System of Ohio, it has been ranked by major institutional rankings among the best pub ...
, where Bristol Laboratories Inc. sponsored his research on the structure of
streptomycin Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, ''Mycobacterium avium'' complex, endocarditis, brucellosis, ''Burkholderia'' infection, plague, tularemia, and rat bite fever. F ...
. He met his future wife, a doctoral student, at Ohio State and they were married in 1948. In following years, he returned to Canada where he spent two years as an
assistant professor Assistant Professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States and Canada. Overview This position is generally taken after earning a doctoral degree A docto ...
at the
University of Saskatchewan A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United State ...
. Next he served as Senior Research Officer at the National Research Council's Prairie Regional Laboratory in
Saskatoon Saskatoon () is the largest city in the Provinces and territories of Canada, Canadian province of Saskatchewan. It straddles a bend in the South Saskatchewan River in the central region of the province. It is located along the Trans-Canada Hig ...
. In 1953 he and a fellow researcher, George Huber, were the first scientists to successfully synthesize
sucrose Sucrose, a disaccharide, is a sugar composed of glucose and fructose subunits. It is produced naturally in plants and is the main constituent of white sugar. It has the molecular formula . For human consumption, sucrose is extracted and refine ...
. In 1954, he accepted the position of
Dean Dean may refer to: People * Dean (given name) * Dean (surname), a surname of Anglo-Saxon English origin * Dean (South Korean singer), a stage name for singer Kwon Hyuk * Dean Delannoit, a Belgian singer most known by the mononym Dean Titles * ...
in the Faculty of Pure and Applied Sciences at the
University of Ottawa The University of Ottawa (french: Université d'Ottawa), often referred to as uOttawa or U of O, is a bilingual public research university in Ottawa, Ontario, Canada. The main campus is located on directly to the northeast of Downtown Ottaw ...
, where he established their Department of Chemistry. In 1961 he returned to the University of Alberta as a professor in the Chemistry Department and to serve as the chairman of the Organic Chemistry Division. He developed a method to make synthetic versions of
oligosaccharides An oligosaccharide (/ˌɑlɪgoʊˈsækəˌɹaɪd/; from the Greek ὀλίγος ''olígos'', "a few", and σάκχαρ ''sácchar'', "sugar") is a saccharide polymer containing a small number (typically two to ten) of monosaccharides (simple suga ...
, which led to improved treatments for
leukemia Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ...
and
hemophilia Haemophilia, or hemophilia (), is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people bleeding for a longer time after an injury, easy bruising ...
and the development of new
antibiotics An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and preventio ...
, blood reagents, and organ anti-rejection drugs. While at the University of Alberta, he established a number of biochemical companies, including R&L Molecular Research Ltd. in 1962, Raylo Chemicals Ltd. in 1966 (which purchased R&L) and Chembiomed in 1977 (which has since been taken over by Synsorb Biotech of
Calgary Calgary ( ) is the largest city in the western Canadian province of Alberta and the largest metro area of the three Prairie Provinces. As of 2021, the city proper had a population of 1,306,784 and a metropolitan population of 1,481,806, maki ...
, Alberta.) Prof. Lemieux published an autobiography, entitled "''Explorations with Sugars: How Sweet It Was''," in 1990. Dr. Raymond Lemieux died of an aneurysm in 2000. In 1999, the
University of Alberta The University of Alberta, also known as U of A or UAlberta, is a Public university, public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexande ...
Faculty of Science and
Strathcona County Strathcona County is a specialized municipality in the Edmonton Metropolitan Region within Alberta, Canada between Edmonton and Elk Island National Park. It forms part of Census Division No. 11. Strathcona County is both urban and rural in ...
established the Strathcona County/R.U. Lemieux Chair in Carbohydrate Chemistry. In 2001, the University of Alberta renamed the building(s) housing the Department of Chemistry to the Gunning/Lemieux Chemistry Centre to acknowledge the contributions of Profs. Raymond Lemieux and Harry Gunning.


Awards

Dr. R.U. Lemieux received numerous awards and honours for his work in chemistry: * Induction into the Royal Society of Canada (1954) * C.S. Hudson Award of the American Chemical Society (1966) * Became the first western Canadian to be elected a fellow of the Royal Society (England) (1967) * Appointed Officer of the
Order of Canada The Order of Canada (french: Ordre du Canada; abbreviated as OC) is a Canadian state order and the second-highest honour for merit in the system of orders, decorations, and medals of Canada, after the Order of Merit. To coincide with the cen ...
(1968) * Haworth Award and Medal (1983) * The Tishler Award, Harvard University (1983) *
Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a ...
(1985) * Made Honorary Doctor of Philosophy from the University of Stockholm (1988) * Induction into the
Alberta Order of Excellence The Alberta Order of Excellence (french: Ordre d'excellence de l'Alberta) is a civilian honour for merit in the Canadian province of Alberta. Instituted in 1979 when Lieutenant Governor Frank C. Lynch-Staunton granted royal assent to the Alberta O ...
(1990) *
King Faisal International Prize The King Faisal Prize ( ar, جائزة الملك فيصل, formerly King Faisal International Prize), is an annual award sponsored by King Faisal Foundation presented to "dedicated men and women whose contributions make a positive difference". T ...
for Science (first Canadian) (1990) *
NSERC The Natural Sciences and Engineering Research Council of Canada (NSERC; french: Conseil de recherches en sciences naturelles et en génie du Canada, CRSNG) is the major federal agency responsible for funding natural sciences and engineering rese ...
Gold Medal in Science (1991) * Albert Einstein World Award of Science (1992) * Made Companion of the
Order of Canada The Order of Canada (french: Ordre du Canada; abbreviated as OC) is a Canadian state order and the second-highest honour for merit in the system of orders, decorations, and medals of Canada, after the Order of Merit. To coincide with the cen ...
(1994) *
Wolf Prize The Wolf Prize is an international award granted in Israel, that has been presented most years since 1978 to living scientists and artists for ''"achievements in the interest of mankind and friendly relations among people ... irrespective of nati ...
in Chemistry (1999)


Notable former trainees

*''David R. Bundle'', former postdoctoral fellow with Prof. Lemieux, currently professor of chemistry, the Raymond U. Lemieux Chair in Carbohydrate Chemistry, and a distinguished university professor at the
University of Alberta The University of Alberta, also known as U of A or UAlberta, is a Public university, public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexande ...
, founder and former director of the Alberta Glycomics Centre (formerly known as Alberta Ingenuity Centre for Carbohydrate Science). http://www.chem.ualberta.ca/~glyco/who/index.htm *''Ole Hindsgaul'', former PhD student with Prof. Lemieux, currently a distinguished professor at the
Carlsberg Laboratory The Carlsberg Research Laboratory is a private scientific research center in Copenhagen, Denmark under the Carlsberg Group. It was founded in 1875 by J. C. Jacobsen, the founder of the Carlsberg brewery, with the purpose of advancing biochemica ...
, Copenhagen, Denmark, and an adjunct professor, Department of Chemistry,
University of Alberta The University of Alberta, also known as U of A or UAlberta, is a Public university, public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexande ...
, Canada. http://www.crc.dk/carbochem/oledraft2.htm


Personal

Raymond's daughter Janet Lemieux was Canadian champion soccer player and was inducted to the Canada Soccer Hall of Fame in 2021.


See also

* Lemieux-Johnson oxidation *
Anomeric effect In organic chemistry, the anomeric effect or Edward-Lemieux effect is a stereoelectronic effect that describes the tendency of heteroatomic substituents adjacent to a heteroatom within a cyclohexane ring to prefer the ''axial'' orientation instea ...
*
Carbohydrate chemistry Carbohydrate chemistry is a subdiscipline of chemistry primarily concerned with the detection, synthesis, structure, and function of carbohydrates. Due to the general structure of carbohydrates, their synthesis is often preoccupied with the sele ...


References


Further reading


The Alberta Order of Excellence Member ProfileScience.ca ProfileRemembering Dr. Lemieux (article)Order of Canada: Raymond U. Lemieux
{{DEFAULTSORT:Lemieux, Raymond 1920 births 2000 deaths Albert Einstein World Award of Science Laureates Canadian chemists Organic chemists Scientists from Alberta Companions of the Order of Canada Members of the Alberta Order of Excellence People from Lac La Biche County University of Alberta alumni University of Alberta faculty Wolf Prize in Chemistry laureates Canadian Fellows of the Royal Society McGill University Faculty of Science alumni Ohio State University alumni 20th-century Canadian scientists 20th-century chemists Canadian expatriates in the United States