RU-28306 is a tricyclic

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...

derivative which acts as a serotonin receptor agonist, with selectivity for 5-HT₁ and 5-HT₂ subtypes. It can be regarded either as a conformationally constrained derivative of DMT, or a structurally simplified analogue of

LSD Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...

, but the

binding affinity In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a m ...

racemic In chemistry, a racemic mixture, or racemate (), is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule or salt. Racemic mixtures are rare in nature, but many compounds are produced industrially as racemates. ...

RU-28306 is closer to that of DMT, though with relatively higher affinity for 5-HT₂ subtypes and lower for 5-HT₁. It has been sold as a

designer drug A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. D ...

and was first reported to the

EMCDDA The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) is an agency of the European Union located in Lisbon, Portugal, and established in 1993. In June 2022, the Council of the European Union approved a reform of the organization ...

by a forensic laboratory in Slovenia in 2017.EMCDDA – Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA
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References

{{Tryptamines Serotonin receptor agonists Tryptamines Phenethylamines

See also

References