RNA recognition motif, RNP-1 is a putative RNA-binding

domain Domain may refer to: Mathematics *Domain of a function, the set of input values for which the (total) function is defined ** Domain of definition of a partial function ** Natural domain of a partial function **Domain of holomorphy of a function * ...

of about 90 amino acids that are known to bind single-stranded RNAs. It was found in many

eukaryotic Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ...

proteins. The largest group of single strand

RNA-binding protein RNA-binding proteins (often abbreviated as RBPs) are proteins that bind to the double or single stranded RNA in cells and participate in forming ribonucleoprotein complexes. RBPs contain various structural motifs, such as RNA recognition motif ...

is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (

hnRNP Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA (pre-mRNA). The presence of the p ...

s), proteins implicated in regulation of

alternative splicing Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be i ...

(SR, U2AF2, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation ( PABP, La, Hu). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor appears to have two RRM-like domains with specialised features for protein recognition. The motif also appears in a few single stranded DNA binding proteins. The typical RRM consists of four anti-parallel beta-strands and two

alpha-helices The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a right hand-helix conformation in which every backbone N−H group hydrogen bonds to the backbone C=O group of the amino acid located four residues ear ...

arranged in a beta-alpha-beta-beta-alpha-beta fold with side chains that stack with RNA bases. A third helix is present during RNA binding in some cases. The RRM is reviewed in a number of publications.

Human proteins containing this domain

A2BP1; ACF; BOLL; BRUNOL4; BRUNOL5; BRUNOL6;

CCBL2 The Cape Cod Baseball League (CCBL or Cape League) is a collegiate summer baseball wooden bat league located on Cape Cod in the U.S. state of Massachusetts. One of the nation's premier collegiate summer leagues, the league boasts over one thousan ...

; CGI-96;

CIRBP Cold-inducible RNA-binding protein is a protein that in humans is encoded by the ''CIRBP'' gene. The cold inducible RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresse ...

;

CNOT4 CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene. Function The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The enc ...

;

CPEB2 CPEB, or cytoplasmic polyadenylation element binding protein, is a highly conserved RNA-binding protein that promotes the elongation of the polyadenine tail of messenger RNA. CPEB most commonly activates the target RNA for translation, but ...

; CPEB3; CPEB4;

CPSF7 Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the ''CPSF7'' gene. Function CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untran ...

;

CSTF2 Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the ''CSTF2'' gene. This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor ( ...

;

CSTF2T Cleavage stimulation factor 64 kDa subunit, tau variant is a protein that in humans is encoded by the ''CSTF2T'' gene. References External links * Further reading

* * * * * * * * * * * * * {{gene-10-stub ...

;

CUGBP1 CUG triplet repeat, RNA binding protein 1, also known as CUGBP1, is a protein which in humans is encoded by the ''CUGBP1'' gene. Function Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, on ...

;

CUGBP2 CUGBP, Elav-like family member 2, also known as Etr-3 is a protein that in humans is encoded by the ''CELF2'' gene. Members of the CELF/BRUNOL protein family are RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains ...

;

D10S102 D1, D01, D.I, D.1 or D-1 can refer to: Science and technology Biochemistry and medicine * ATC code D01 ''Antifungals for dermatological use'', a subgroup of the Anatomical Therapeutic Chemical Classification System * Dopamine receptor D1, a prote ...

;

DAZ1 Deleted in azoospermia 1, also known as DAZ1, is a protein which in humans is encoded by the ''DAZ1'' gene. Function This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its e ...

; DAZ2; DAZ3; DAZ4; DAZAP1;

DAZL Deleted in azoospermia-like is a protein that in humans is encoded by the ''DAZL'' gene. Function The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of ...

; DNAJC17; DND1; EIF3S4; EIF3S9;

EIF4B Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the ''EIF4B'' gene. Interactions eIF4B has been shown to interact with and stimulate the activity of eIF4A and bind to the eIF3 complex through the eIF3A su ...

; EIF4H;

ELAVL1 ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ''ELAVL1'' gene. The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds ci ...

; ELAVL2; ELAVL3; ELAVL4; ENOX1; ENOX2; EWSR1; FUS; FUSIP1; G3BP;

G3BP1 Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the ''G3BP1'' gene. This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/ ...

;

G3BP2 Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the ''G3BP2'' gene. Interactions G3BP2 has been shown to interact with IκBα IκBα (nuclear factor of kappa light polypeptide gene enhancer in B- ...

; GRSF1; HNRNPL; HNRPA0; HNRPA1;

HNRPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the ''HNRNPA2B1'' gene. Structure ''HNRNPA2B1'' gene contains 12 exons, including a B1 protein specific 36-nucleotide mini-exon. The entire length of intron ...

;

HNRPA3 Heterogeneous nuclear ribonucleoprotein A3 is a protein that in humans is encoded by the ''HNRNPA3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meani ...

;

HNRPAB Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRNPAB, is a protein which in humans is encoded by the ''HNRNPAB'' gene. Although this gene is named ''HNRNPAB'' in reference to its first cloning as an RNA binding protein with similarit ...

; HNRPC; HNRPCL1; HNRPD;

HNRPDL Heterogeneous nuclear ribonucleoprotein D-like, also known as HNRPDL, is a protein which in humans is encoded by the ''HNRPDL'' gene. Function This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoprot ...

; HNRPF; HNRPH1; HNRPH2; HNRPH3; HNRPL; HNRPLL; HNRPM; HNRPR; HRNBP1; HSU53209;

HTATSF1 HIV Tat-specific factor 1 is a protein that in humans is encoded by the ''HTATSF1'' gene. Function Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immu ...

; IGF2BP1; IGF2BP2; IGF2BP3; LARP7; MKI67IP;

MSI1 RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the ''MSI1'' gene. Function This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA b ...

; MSI2; MSSP-2; MTHFSD; MYEF2; NCBP2; NCL; NOL8; NONO; P14;

PABPC1 Polyadenylate-binding protein 1 is a protein that in humans is encoded by the ''PABPC1'' gene. The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stabili ...

; PABPC1L; PABPC3; PABPC4; PABPC5;

PABPN1 Polyadenylate-binding protein 2 (PABP-2) also known as polyadenylate-binding nuclear protein 1 (PABPN1) is a protein that in humans is encoded by the ''PABPN1'' gene. PABN1 is a member of a larger family of poly(A)-binding proteins in the human ge ...

; POLDIP3; PPARGC1;

PPARGC1A Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the ''PPARGC1A'' gene. PPARGC1A is also known as human accelerated region 20 ( HAR20). It may, therefore, have played a key r ...

; PPARGC1B; PPIE;

PPIL4 Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the ''PPIL4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ...

; PPRC1; PSPC1; PTBP1;

PTBP2 Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the ''PTBP2'' gene. Function The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream contro ...

; PUF60; RALY; RALYL; RAVER1; RAVER2; RBM10; RBM11; RBM12; RBM12B; RBM14; RBM15; RBM15B; RBM16; RBM17; RBM18; RBM19; RBM22; RBM23; RBM24; RBM25; RBM26; RBM27; RBM28;

RBM3 Putative RNA-binding protein 3 is a protein that in humans is encoded by the ''RBM3'' gene. Function This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expres ...

; RBM32B; RBM33; RBM34; RBM35A; RBM35B; RBM38; RBM39; RBM4; RBM41; RBM42; RBM44; RBM45; RBM46; RBM47; RBM4B; RBM5; RBM7;

RBM8A RNA-binding protein 8A is a protein that in humans is encoded by the ''RBM8A'' gene. This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. ...

;

RBM9 RNA binding motif protein 9 (RBM9), also known as Rbfox2, is a protein which in humans is encoded by the ''RBM9'' gene. Function Rbfox2 is one of several human genes similar to the '' C. elegans'' gene Fox-1. This gene encodes an RNA bindi ...

; RBMS1; RBMS2; RBMS3;

RBMX Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the ''RBMX'' gene. Function This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chrom ...

; RBMX2; RBMXL2; RBMY1A1; RBMY1B; RBMY1E; RBMY1F; RBMY2FP; RBPMS; RBPMS2;

RDBP Negative elongation factor E is a protein that in humans is encoded by the ''RDBP'' gene. Function The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elo ...

; RNPC3; RNPC4;

RNPS1 RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the ''RNPS1'' gene. Function This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both ...

; ROD1; SAFB; SAFB2; SART3; SETD1A;

SF3B14 Splicing factor 3B, 14 kDa subunit, also known as SF3B14, is a human gene. Function This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucle ...

;

SF3B4 Splicing factor 3B subunit 4 is a protein that in humans is encoded by the ''SF3B4'' gene. Function This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA imme ...

; SFPQ; SFRS1; SFRS10;

SFRS11 Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the ''SFRS11'' gene. This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. ...

; SFRS12; SFRS15; SFRS2; SFRS2B; SFRS3;

SFRS4 Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the ''SFRS4'' gene. Interactions SFRS4 has been shown to interact with Pinin Pinin is a protein that in humans is encoded by the ''PNN'' gene. Interactions Pin ...

; SFRS5; SFRS6; SFRS7; SFRS9; SLIRP; SLTM;

SNRP70 snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the ''SNRNP70'' gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core co ...

; SNRPA; SNRPB2; SPEN; SR140; SRRP35; SSB; SYNCRIP;

TAF15 TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the ''TAF15'' gene. Function Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates ...

;

TARDBP TAR DNA-binding protein 43 (TDP-43, transactive response DNA binding protein 43 kDa) is a protein that in humans is encoded by the ''TARDBP'' gene. Structure TDP-43 is 414 amino acid residues long. It consists of 4 domains: an N-terminal ...

; THOC4;

TIA1 TIA1 or Tia1 cytotoxic granule-associated rna binding protein is a 3'UTR mRNA binding protein that can bind the 5'TOP sequence of 5'TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gen ...

; TIAL1; TNRC4; TNRC6C; TRA2A; TRSPAP1; TUT1; U1SNRNPBP;

U2AF1 Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the ''U2AF1'' gene. Function This gene belongs to the splicing factor SR family of genes . U2AF1 is a subunit of the U2 Auxiliary Factor complex alongside a large ...

; U2AF2; UHMK1; ZCRB1; ZNF638; ZRSR1; ZRSR2;

References

External links

* {{InterPro content, IPR000504 Protein domains