Ras-related protein Rab-5A is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''RAB5A''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
RAB5A localizes to early
endosome
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can ...
s where it is involved in the recruitment of
RAB7A
Ras-related protein Rab-7a is a protein that in humans is encoded by the ''RAB7A'' gene.
Ras-related protein Rab-7a is involved in endocytosis, which is a process that brings substances into a cell. The process of endocytosis works by folding the ...
and the maturation of these compartments to late endosomes. It drives the maturation of endosomes by transporting
vacuolar (H+)-ATPases (V-ATPases) from trans-Golgi network to endocytic vesicles.
Interactions
RAB5A has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
CHML
CHML is a radio station, broadcasting at 900 AM in Hamilton, Ontario, Canada. CHML's transmitter power is 50,000 watts using an eight-tower directional antenna array with a signal oriented largely west-northwest to east-southeast, covering the ...
,
*
RABEP1
Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the ''RABEP1'' gene. It belongs to rabaptin protein family.
Interactions
RABEP1 has been shown to interact with:
* AP1G1,
* GGA1,
* GGA2,
* RAB4A, and
* RAB5A ...
,
*
SDCBP
Syntenin-1 is a protein that in humans is encoded by the ''SDCBP'' gene.
Function
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains ta ...
,
and
*
ZFYVE20
Rabenosyn-5 is a protein that in humans is encoded by the ''ZFYVE20'' gene.
Interactions
ZFYVE20 has been shown to interact with RAB5A
Ras-related protein Rab-5A is a protein that in humans is encoded by the ''RAB5A'' gene.
Function
RAB5A ...
References
Further reading
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{{PDB Gallery, geneid=5868