Ryszard Kole
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Ryszard Kole (Polish: ) is a Polish-American pharmacologist and professor emeritus in the Pharmacology Department at the
UNC School of Medicine The University of North Carolina School of Medicine is a professional school within the University of North Carolina at Chapel Hill. It offers a Doctor of Medicine degree along with combined Doctor of Medicine / Doctor of Philosophy or Doctor o ...
within the University of North Carolina at Chapel Hill. He is known for his research on control of
gene expression Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. The ...
by antisense oligonucleotides and
messenger RNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the p ...
-based therapeutics. He is the recipient of the 2019 Massry Prize.


Life and career

He graduated in chemistry from the University of Warsaw in 1969. Between 1970–1977, he held the position of senior research associate at the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences (PAN), where he obtained his PhD degree. His research there mostly concerned the role of ribonucleases on cell function. In 1977, he moved to the United States where, as a postdoctoral fellow, he trained with Sidney Altman and Sherman Wiseman at Yale University. In 1983, joined the faculty of the University of North Carolina at Chapel Hill as Professor of Pharmacology. In 2019, he became the joint recipient of the Massry Prize, alongsdie Stanley T. Crooke, for "their seminal work in the development of oligonucleotides targeting messenger RNA as novel therapeutics for a wide range human diseases".


See also

* List of Polish scientists * List of Polish-Americans


References

{{DEFAULTSORT:Kole, Ryszard American people of Polish descent Polish pharmacologists American pharmacologists University of Warsaw alumni University of North Carolina at Chapel Hill faculty Year of birth missing (living people) Living people