The SdsR/RyeB RNA is a
non-coding RNA
A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene. Abundant and functionally important types of non-c ...
that was identified in a large scale screen of ''
E. coli
''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escher ...
''. The exact 5′ and 3′ ends of this RNA are uncertain. This RNA overlaps the
SraC/RyeA RNA on the opposite strand suggesting that the two may act in a concerted manner. It is transcribed by general stress factor σ
s and is most highly expressed in stationary phase. SdsR/RyeB RNA interacts with
Hfq
The Hfq protein (also known as HF-I protein) encoded by the ''hfq'' gene was discovered in 1968 as an ''Escherichia coli'' host factor that was essential for replication of the bacteriophage Qβ. It is now clear that Hfq is an abundant bacterial RN ...
.
The homologous sRNA in ''
S. enterica
''Salmonella enterica'' (formerly ''Salmonella choleraesuis'') is a Bacillus (shape), rod-headed, flagellate, Facultative anaerobic organism, facultative anaerobic, Gram-negative bacteria, Gram-negative bacterium and a species of the genus ''Salm ...
'' was shown to regulate synthesis of major porin OmpD. A study using ''Salmonella'' identified 20 targets of this sRNA including transcriptional regulator, CRP, global DNA-binding factors, StpA and HupB, the antibiotic transporter protein, TolC, and the RtsA/B two-component system (TCS), and validated their post-transcriptional control by SdsR/RyeB RNA.
See also
*
RydB RNA
*
RyhB RNA
RyhB RNA is a 90 nucleotide RNA that down-regulates a set of iron-storage and iron-using proteins when iron is limiting; it is itself negatively regulated by the ferric uptake repressor protein, Fur ( Ferric uptake regulator).
Discovery
The gene ...
*
RyeE RNA
The CyaR RNA (formerly known as RyeE RNA) non-coding RNA was identified in a large scale screen of ''Escherichia coli'' and was called candidate 14. The exact 5′ and 3′ ends of this RNA are uncertain. This gene lies between yegQ and orgK in '' ...
References
External links
Non-coding RNA
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