In genetics, rs28363170 (DAT1-VNTR) is a genetic variation at ''
SLC6A3
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopami ...
'', the gene that encodes the
dopamine transporter. It is polymorphism as a 40 base pairs
VNTR
A variable number tandem repeat (or VNTR) is a location in a genome where a short nucleotide sequence is organized as a tandem repeat. These can be found on many chromosomes, and often show Polymorphism (biology), variations in length (number of ...
in the 3' untranslated region.
It is a
deletion/insertion polymorphism (DIP).
The 9-repeat and the 10-repeat are the most common alleles.
References
Further
*
* {{Cite journal
, doi = 10.1038/sj.npp.1301240
, year = 2007
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, title = Dopamine transporter 3'-UTR VNTR genotype and ADHD: a pharmaco-behavioural genetic study with methylphenidate
, journal = Neuropsychopharmacology
, volume = 32
, issue = 6
, pages = 1370–1376
, pmid = 17063150
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, s2cid = 2944059