Route 25 is a highway in south-eastern

Missouri Missouri is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it is bordered by eight states (tied for the most with Tennessee ...

. Its northern terminus is at Business

Interstate 55 Interstate 55 (I-55) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route, connecting the Gulf of Mexico to the Great Lakes. The h ...

U.S. Route 61 U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends between New Orleans, Louisiana and the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River and is designate ...

Route 34 The following highways are numbered 34: for a list of roads numbered N34 : see list of N34 roads. International * AH34, Asian Highway 34 * European route E34 Australia * Cox Peninsula Road (Northern Territory) * (Sydney) * Maroondah Highway (Vi ...

Jackson Jackson may refer to: People and fictional characters * Jackson (name), including a list of people and fictional characters with the surname or given name Places Australia * Jackson, Queensland, a town in the Maranoa Region * Jackson North, Q ...

. Its southern terminus is at

U.S. Route 412 U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from east of Chouteau, Oklahoma, to west of the ...

/ Route 84 in Kennett. Route 25 was one of the original 1922 state highways. Its original northern terminus was at Route 9 in

Festus Festus may refer to: People Ancient world *Porcius Festus, Roman governor of Judea from approximately 58 to 62 AD *Sextus Pompeius Festus (later 2nd century), Roman grammarian *Festus (died 305), martyr along with Proculus of Pozzuoli *Festus (h ...

. In 1926, with the creation of the

U.S. Highway system The United States Numbered Highway System (often called U.S. Routes or U.S. Highways) is an integrated network of roads and highways numbered within a nationwide grid in the contiguous United States. As the designation and numbering of these h ...

, Route 9 from

St. Louis St. Louis () is the second-largest city in Missouri, United States. It sits near the confluence of the Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, while the bi-state metropolitan area, which e ...

Hematite Hematite (), also spelled as haematite, is a common iron oxide compound with the formula, Fe2O3 and is widely found in rocks and soils. Hematite crystals belong to the rhombohedral lattice system which is designated the alpha polymorph of . ...

became part of

, which was then routed down Route 25 to Jackson, moving Route 25's northern terminus to Jackson, too. Until February 1981,Highways Marked

Southeast Missourian ''The Southeast Missourian'' is a 3 day per week newspaper published in Cape Girardeau, Missouri, and serves (as the name implies) the southeastern portion of Missouri. History The paper began publication on October 3, 1904 as ''The Daily Rep ...

, February 3, 1981 when U.S. Route 412 was designated across the southernmost section, "the Bootheel", thus supplanting Route 25 south and west of Kennett, Route 25 passed

Senath Senath () is a city in Dunklin County, Missouri, United States. The population was 1,767 at the 2010 census. History Senath was founded in 1882. It is named after an early settler, Asenath Douglass, who was commonly called Senath and in whose f ...

and Arbyrd, taking a sharp westward turn and heading across the

St. Francis River The St. Francis River is a tributary of the Mississippi River, about long, in southeastern Missouri and northeastern Arkansas in the United States. The river drains a mostly rural area and forms part of the Missouri-Arkansas state line along the ...

and the

Arkansas Arkansas ( ) is a landlocked state in the South Central United States. It is bordered by Missouri to the north, Tennessee and Mississippi to the east, Louisiana to the south, and Texas and Oklahoma to the west. Its name is from the Osage ...

border, feeding westward to join the former Arkansas Highway 25 (now U.S. 412) toward

Paragould, Arkansas Paragould is the county seat of Greene County, and the 19th-largest city in Arkansas, in the United States. The city is located in northeastern Arkansas on the eastern edge of Crowley's Ridge, a geologic anomaly contained within the Arkansas delta ...

. The old section of Route 25 south and west of Kennett now bears

Missouri supplemental route A supplemental route is a state secondary road in the U.S. state of Missouri, designated with letters. Supplemental routes were various roads within the state which the Missouri Department of Transportation was given in 1952 to maintain in additio ...

designations.

Major intersections

Business loop

A three mile business route of MO 25 exists in Malden.

References

025 5 (five) is a number, numeral and digit. It is the natural number, and cardinal number, following 4 and preceding 6, and is a prime number. It has attained significance throughout history in part because typical humans have five digits on eac ...

Transportation in Dunklin County, Missouri Transportation in New Madrid County, Missouri Transportation in Stoddard County, Missouri Transportation in Cape Girardeau County, Missouri {{Missouri-road-stub