Roseophilin is an antibiotic isolated from '' Streptomyces griseoviridis'' shown to have antitumor activity. The chemical structure can be considered in terms of two components, a macrotricyclic segment and a

heterocyclic A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of its ring(s). Heterocyclic chemistry is the branch of organic chemistry dealing with the synthesis, properties, and ...

side-chain. Several laboratory syntheses of roseophilin (e.g., those of

Trost Trost may refer to: People * Al Trost, United States soccer midfielder * Barry Trost, American chemist * Brad Trost, Canadian Member of Parliament * Carlisle Trost, United States Navy officer * Dolfi Trost, Romanian surrealist * Katharina Trost, G ...

, Fürstner, Salamone) are based upon the Paal-Knorr synthesis, and two others are based on the Nazarov cyclization reaction (those of Tius, Frontier). The compound is related to the

prodiginines The prodiginines are a family of red tri pyrrole dyestuffs produced by Gammaproteobacteria (e.g. '' Serratia marcescens'') as well as some Actinomycetota (e.g. ''Streptomyces coelicolor''). The group is named after prodigiosin (prodiginine) and ...

References

Antibiotics Pyrroles Furans Chloroarenes Phenol ethers {{antibiotic-stub