Robert Ellis Shope (February 21, 1929
– January 19, 2004) was an American
virologist
Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, their ...
,
epidemiologist
Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and risk factor, determinants of health and disease conditions in a defined population.
It is a cornerstone of public health, and shapes policy decision ...
and
public health
Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals". Analyzing the det ...
expert, particularly known for his work on
arthropod-borne viruses and
emerging infectious disease
An emerging infectious disease (EID) is an infectious disease whose incidence has increased recently (in the past 20 years), and could increase in the near future. The minority that are capable of developing efficient transmission between human ...
s. He discovered more
novel virus
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea.
Since Dmitri Ivanovsky's ...
es than any person previously, including members of the ''
Arenavirus
An arenavirus is a bisegmented ambisense RNA virus that is a member of the family ''Arenaviridae''. These viruses infect rodents and occasionally humans. A class of novel, highly divergent arenaviruses, properly known as reptarenaviruses, have ...
'', ''
Hantavirus
''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family ''Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses.
Orthohantav ...
'', ''
Lyssavirus
''Lyssavirus'' (from the Greek ''lyssa'' "rage, fury, rabies" and the Latin '' vīrus'') is a genus of RNA viruses in the family ''Rhabdoviridae'', order ''Mononegavirales''. Mammals, including humans, can serve as natural hosts. The genus ' ...
'' and ''
Orbivirus
''Orbivirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae'' and subfamily ''Sedoreovirinae''. Unlike other reoviruses, orbiviruses are arboviruses. They can infect and replicate within a wide range of arthropod and verte ...
''
genera
Genus ( plural genera ) is a taxonomic rank used in the biological classification of living and fossil organisms as well as viruses. In the hierarchy of biological classification, genus comes above species and below family. In binomial nomenclat ...
of
RNA virus
An RNA virus is a virusother than a retrovirusthat has ribonucleic acid (RNA) as its genetic material. The nucleic acid is usually single-stranded RNA ( ssRNA) but it may be double-stranded (dsRNA). Notable human diseases caused by RNA viruses ...
es. He researched significant human diseases, including
dengue
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic ...
,
Lassa fever
Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by the Lassa virus. Many of those infected by the virus do not develop symptoms. When symptoms occur they typically include fever, weakness, h ...
,
Rift Valley fever,
yellow fever
Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. In ...
, viral hemorrhagic fevers and
Lyme disease
Lyme disease, also known as Lyme borreliosis, is a vector-borne disease caused by the ''Borrelia'' bacterium, which is spread by ticks in the genus ''Ixodes''. The most common sign of infection is an expanding red rash, known as erythema migran ...
. He had an encyclopedic knowledge of viruses, and curated a global reference collection of over 5,000 viral strains. He was the lead author of a groundbreaking report on the threat posed by emerging infectious diseases, and also advised on
climate change
In common usage, climate change describes global warming—the ongoing increase in global average temperature—and its effects on Earth's climate system. Climate change in a broader sense also includes previous long-term changes to E ...
and
bioterrorism
Bioterrorism is terrorism involving the intentional release or dissemination of biological agents. These agents are bacteria, viruses, insects, fungi, and/or toxins, and may be in a naturally occurring or a human-modified form, in much the same ...
.
Biography
Born in 1929 in
Princeton
Princeton University is a private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth as the College of New Jersey, Princeton is the fourth-oldest institution of higher education in the United States and one of the nine ...
,
New Jersey
New Jersey is a state in the Mid-Atlantic and Northeastern regions of the United States. It is bordered on the north and east by the state of New York; on the east, southeast, and south by the Atlantic Ocean; on the west by the Delaware ...
, Shope was the son of
Richard E. Shope, also a prominent virologist.
His brothers, Richard E. Shope, Jr and Thomas C. Shope, were also virologists. Shope attended Cornell University
Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach an ...
, where he gained a BA in zoology (1951) and an MD (1954). After an internship at Yale School of Medicine
The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813.
The primary te ...
, Shope joined the U.S. Army Medical Corps
The Medical Corps (MC) of the U.S. Army is a staff corps (non-combat specialty branch) of the U.S. Army Medical Department (AMEDD) consisting of commissioned medical officers – physicians with either an M.D. or a D.O. degree, at least one ye ...
and served for a total of three years at Camp Detrick
Fort Detrick () is a United States Army Futures Command installation located in Frederick, Maryland. Historically, Fort Detrick was the center of the U.S. biological weapons program from 1943 to 1969. Since the discontinuation of that program, i ...
in Frederick Frederick may refer to:
People
* Frederick (given name), the name
Nobility
Anhalt-Harzgerode
*Frederick, Prince of Anhalt-Harzgerode (1613–1670)
Austria
* Frederick I, Duke of Austria (Babenberg), Duke of Austria from 1195 to 1198
* Frederick ...
, Maryland
Maryland ( ) is a state in the Mid-Atlantic region of the United States. It shares borders with Virginia, West Virginia, and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware and the Atlantic Ocean to ...
and then at the U.S. Army Medical Research Unit in Kuala Lumpur
, anthem = '' Maju dan Sejahtera''
, image_map =
, map_caption =
, pushpin_map = Malaysia#Southeast Asia#Asia
, pushpin_map_caption =
, coordinates =
, su ...
, Malaysia. He subsequently joined the Rockefeller Foundation
The Rockefeller Foundation is an American private foundation and philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The second-oldest major philanthropic institution in America, after the Carneg ...
and – after a year studying with Max Theiler
Max Theiler (30 January 1899 – 11 August 1972) was a South African-American virologist and physician. He was awarded the Nobel Prize in Physiology or Medicine in 1951 for developing a vaccine against yellow fever in 1937, becoming the first ...
in New York – he was posted to Belém
Belém (; Portuguese for Bethlehem; initially called Nossa Senhora de Belém do Grão-Pará, in English Our Lady of Bethlehem of Great Pará) often called Belém of Pará, is a Brazilian city, capital and largest city of the state of Pará in t ...
, Brazil, at the foundation's International Virus Program, where he spent six years, rising to direct the institute.
Returning to the US in 1965, Shope joined the recently established Yale Arbovirus Research Unit (YARU) at Yale School of Medicine with other virologists from the Rockefeller Foundation. Initially an associate professor, he rose to direct the unit for 24 years. Shope also headed the university's Division of Infectious Disease Epidemiology. After his retirement from Yale in 1995, Shope and his colleague Robert B. Tesh moved to the University of Texas Medical Branch
The University of Texas Medical Branch (UTMB) is a public academic health science center in Galveston, Texas. It is part of the University of Texas System. UTMB includes the oldest medical school in Texas, and has about 11,000 employees. In Febr ...
at Galveston
Galveston ( ) is a coastal resort city and port off the Southeast Texas coast on Galveston Island and Pelican Island in the U.S. state of Texas. The community of , with a population of 47,743 in 2010, is the county seat of surrounding Galvesto ...
, Texas
Texas (, ; Spanish language, Spanish: ''Texas'', ''Tejas'') is a state in the South Central United States, South Central region of the United States. At 268,596 square miles (695,662 km2), and with more than 29.1 million residents in 2 ...
, where they founded a new arbovirus
Arbovirus is an informal name for any virus that is transmitted by arthropod vectors. The term ''arbovirus'' is a portmanteau word (''ar''thropod-''bo''rne ''virus''). ''Tibovirus'' (''ti''ck-''bo''rne ''virus'') is sometimes used to more spe ...
centre. Shope subsequently held the university's John S. Dunn Distinguished Chair in Biodefense.
Research
The virologist Charles Calisher Charles Calisher is professor emeritus of microbiology at the College of Veterinary Medicine & Biomedical Sciences at Colorado State University.
Education and career
Calisher received a bachelor's degree in bacteriology from the Philadelphia Col ...
described Shope as a "walking encyclopaedia on the arbovirus catalogue," and during his career Shope contributed to the discovery of hundreds of novel viruses – more than any person previously. His research encompassed not only the areas of virology
Virology is the Scientific method, scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host (biology), ...
, tropical
The tropics are the regions of Earth surrounding the Equator. They are defined in latitude by the Tropic of Cancer in the Northern Hemisphere at N and the Tropic of Capricorn in
the Southern Hemisphere at S. The tropics are also referred to ...
and emerging infectious disease
An emerging infectious disease (EID) is an infectious disease whose incidence has increased recently (in the past 20 years), and could increase in the near future. The minority that are capable of developing efficient transmission between human ...
s, but also epidemiology
Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population.
It is a cornerstone of public health, and shapes policy decisions and evidenc ...
, vector biology and public health
Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals". Analyzing the det ...
. Calisher and emerging infectious disease specialist C. J. Peters highlighted his multidisciplinary approach, stating that "He brought the virus community together and served as a bridge between classical arbovirology and many other disciplines" including ecology
Ecology () is the study of the relationships between living organisms, including humans, and their physical environment. Ecology considers organisms at the individual, population, community, ecosystem, and biosphere level. Ecology overlaps wi ...
, genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar wor ...
and structural biology
Structural biology is a field that is many centuries old which, and as defined by the Journal of Structural Biology, deals with structural analysis of living material (formed, composed of, and/or maintained and refined by living cells) at every le ...
. Epidemiologist and emerging infectious disease specialist Stephen S. Morse considered Shope to exemplify the approach of "integrating the laboratory and the epidemiological and being able to think broadly about the evolutionary issues as well as the specifics."
Shope initially studied the Australian disease then known as " epidemic polyarthritis" with S. G. Anderson, showing that it was caused by an alphavirus
''Alphavirus'' is a genus of RNA viruses, the sole genus in the ''Togaviridae'' family. Alphaviruses belong to group IV of the Baltimore classification of viruses, with a positive-sense, single-stranded RNA genome. There are 32 alphaviruses, ...
, later characterised as Ross River virus
''Ross River virus'' (RRV) is a small encapsulated single-strand RNA ''Alphavirus'' endemic to Australia, Papua New Guinea and other islands in the South Pacific. It is responsible for a type of mosquito-borne non-lethal but extremely debilita ...
. His interest in infectious diseases was stimulated by his military service in Malaysia, where he investigated fevers among army personnel and locals. During his time in Brazil in the early 1960s, he characterised over fifty different arbovirus
Arbovirus is an informal name for any virus that is transmitted by arthropod vectors. The term ''arbovirus'' is a portmanteau word (''ar''thropod-''bo''rne ''virus''). ''Tibovirus'' (''ti''ck-''bo''rne ''virus'') is sometimes used to more spe ...
es (viruses transmitted by arthropod
Arthropods (, (gen. ποδός)) are invertebrate animals with an exoskeleton, a Segmentation (biology), segmented body, and paired jointed appendages. Arthropods form the phylum Arthropoda. They are distinguished by their jointed limbs and Arth ...
s) including Guama and Oropouche virus
''Oropouche orthobunyavirus'' (OROV) is one of the most common orthobunyaviruses. When OROV infects humans, it causes a rapid fever illness called Oropouche fever. OROV was originally reported in Trinidad and Tobago in 1955 from the blood sample o ...
es, many previously unknown. He also studied the viruses' vertebrate
Vertebrates () comprise all animal taxa within the subphylum Vertebrata () ( chordates with backbones), including all mammals, birds, reptiles, amphibians, and fish. Vertebrates represent the overwhelming majority of the phylum Chordata, ...
reservoirs, including bird
Birds are a group of warm-blooded vertebrates constituting the class Aves (), characterised by feathers, toothless beaked jaws, the laying of hard-shelled eggs, a high metabolic rate, a four-chambered heart, and a strong yet lightweigh ...
s, marsupial
Marsupials are any members of the mammalian infraclass Marsupialia. All extant marsupials are endemic to Australasia, Wallacea and the Americas. A distinctive characteristic common to most of these species is that the young are carried in a po ...
s and rodent
Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia (), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are na ...
s.
Later that decade while at YARU, he characterised novel arboviruses from birds in Egypt. In 1969, his research turned to outbreaks of Lassa and yellow fever
Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. In ...
in Nigeria. The following year, with Frederick A. Murphy, he discovered Duvenhage, Lagos bat and Mokola viruses, which were the first viruses shown to be related to rabies
Rabies is a viral disease that causes encephalitis in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: nausea, vomiting, vi ...
. He characterised Thottapalayam virus
''Thottopalayam thottimvirus'', formerly ''Thottapalayam virus'', (TMPV) is single-stranded, enveloped, negative-sense RNA virus species of the genus '' Thottimvirus'' in the ''Bunyavirales'' order. It is the first hantavirus to be isolated from ...
, later shown to be the first hantavirus
''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family ''Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses.
Orthohantav ...
, from an Indian shrew
Shrews (family Soricidae) are small mole-like mammals classified in the order Eulipotyphla. True shrews are not to be confused with treeshrews, otter shrews, elephant shrews, West Indies shrews, or marsupial shrews, which belong to different fa ...
in 1971. With Murphy and others, he discovered multiple viruses related to bluetongue
Bluetongue disease is a noncontagious, insect-borne, viral disease of ruminants, mainly sheep and less frequently cattle, yaks, goats, buffalo, deer, dromedaries, and antelope. It is caused by ''Bluetongue virus'' (''BTV''). The virus i ...
, including bluetongue 20 virus
Bluetongue disease is a infectious disease#Contagiousness, noncontagious, vector (epidemiology), insect-borne, virus, viral disease of ruminants, mainly domestic sheep, sheep and less frequently cattle, yaks, goats, Bovinae, buffalo, deer, drome ...
, the first bluetongue-like virus from Australia. In the late 1970s, with Jim Meegan, he showed that Rift Valley fever virus
In geology, a rift is a linear zone where the lithosphere is being pulled apart and is an example of extensional tectonics.
Typical rift features are a central linear downfaulted depression, called a graben, or more commonly a half-graben wi ...
– previously believed to be restricted to sub-Saharan Africa, and mainly to infect livestock – was the cause of an epidemic in Egypt in which around 200,000 people were infected. With Allan Steer, he was the first to describe Lyme disease
Lyme disease, also known as Lyme borreliosis, is a vector-borne disease caused by the ''Borrelia'' bacterium, which is spread by ticks in the genus ''Ixodes''. The most common sign of infection is an expanding red rash, known as erythema migran ...
, a tick
Ticks (order Ixodida) are parasitic arachnids that are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, species, and "fullness". Ticks are external parasites, living by ...
-borne bacterial disease, in the US. He subsequently worked on viral hemorrhagic fevers, discovering Sabiá and Guanarito virus
Venezuelan hemorrhagic fever (VHF) is a zoonotic human illness first identified in 1989. The disease is most prevalent in several rural areas of central Venezuela and is caused by ''Guanarito mammarenavirus'' (GTOV) which belongs to the Arenaviri ...
es, the causative agents of Brazilian and Venezuelan hemorrhagic fever
Venezuelan hemorrhagic fever (VHF) is a zoonotic human illness first identified in 1989. The disease is most prevalent in several rural areas of central Venezuela and is caused by ''Guanarito mammarenavirus'' (GTOV) which belongs to the Arenavir ...
s. He also researched dengue
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic ...
and its vaccines.
During Shope's time at Yale, YARU became the global repository for arboviruses. When he and Tesh moved to University of Texas Medical Branch
The University of Texas Medical Branch (UTMB) is a public academic health science center in Galveston, Texas. It is part of the University of Texas System. UTMB includes the oldest medical school in Texas, and has about 11,000 employees. In Febr ...
in 1995, they brought the arbovirus collection – consisting of more than 4,000 strains of arbovirus and more than 1,000 other viral strains, as well as reagents such as antibodies – with them. The collection is used by scientists internationally to identify virus strains. At Galveston, Shope widened his focus to include bioterrorism
Bioterrorism is terrorism involving the intentional release or dissemination of biological agents. These agents are bacteria, viruses, insects, fungi, and/or toxins, and may be in a naturally occurring or a human-modified form, in much the same ...
, winning $3.7 million in funding to develop measures to counter the threat. His group identified alphavirus, arenavirus
An arenavirus is a bisegmented ambisense RNA virus that is a member of the family ''Arenaviridae''. These viruses infect rodents and occasionally humans. A class of novel, highly divergent arenaviruses, properly known as reptarenaviruses, have ...
and flavivirus
''Flavivirus'' is a genus of positive-strand RNA viruses in the family ''Flaviviridae''. The genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may caus ...
as potential bioterrorist risks, and Shope worked with structural biologist David Gorenstein to develop new small-molecule antivirals
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do no ...
targeted against these viruses.
Public health and advisory work
Shope led a high-profile investigation, with Joshua Lederberg
Joshua () or Yehoshua ( ''Yəhōšuaʿ'', Tiberian: ''Yŏhōšuaʿ,'' lit. 'Yahweh is salvation') ''Yēšūaʿ''; syr, ܝܫܘܥ ܒܪ ܢܘܢ ''Yəšūʿ bar Nōn''; el, Ἰησοῦς, ar , يُوشَعُ ٱبْنُ نُونٍ '' Yūšaʿ ...
and Stanley Oaks, into the risks posed by emerging infectious disease
An emerging infectious disease (EID) is an infectious disease whose incidence has increased recently (in the past 20 years), and could increase in the near future. The minority that are capable of developing efficient transmission between human ...
s and the measures necessary to respond to them for the Institute of Medicine
The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, E ...
. The findings were published in 1992 as ''Emerging Infections: Microbial Threats to Health in the United States'', with Shope as the principal author, and the publication was swiftly recognised as groundbreaking. It suggested that the success of vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifie ...
s and antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
s had led to the threat of infectious diseases being underestimated. Shope stated at the press conference announcing the report's publication: "The medical community and society at large have tended to view acute infectious diseases as a problem of the past. But that assumption is wrong. We claimed victory too soon." The report was important in improving the detection of infectious diseases in the US, and has been credited with stimulating renewed global interest in the area. Shope continued to advise the US government on the topic later in the 1990s, and contributed to the establishment of American and international surveillance programs for infectious diseases including ProMED.
Shope was one of seven scientists to brief Bill Clinton
William Jefferson Clinton ( né Blythe III; born August 19, 1946) is an American politician who served as the 42nd president of the United States from 1993 to 2001. He previously served as governor of Arkansas from 1979 to 1981 and agai ...
and Al Gore
Albert Arnold Gore Jr. (born March 31, 1948) is an American politician, businessman, and environmentalist who served as the 45th vice president of the United States from 1993 to 2001 under President Bill Clinton. Gore was the Democratic Part ...
in 1997 on the effects of climate change
In common usage, climate change describes global warming—the ongoing increase in global average temperature—and its effects on Earth's climate system. Climate change in a broader sense also includes previous long-term changes to E ...
, warning that the range of mosquito
Mosquitoes (or mosquitos) are members of a group of almost 3,600 species of small flies within the family Culicidae (from the Latin ''culex'' meaning " gnat"). The word "mosquito" (formed by ''mosca'' and diminutive ''-ito'') is Spanish for "li ...
es and other arthropod
Arthropods (, (gen. ποδός)) are invertebrate animals with an exoskeleton, a Segmentation (biology), segmented body, and paired jointed appendages. Arthropods form the phylum Arthropoda. They are distinguished by their jointed limbs and Arth ...
vectors would increase, affecting the prevalence of dengue
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic ...
, malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...
and other infectious diseases. He also served on the WHO
Who or WHO may refer to:
* Who (pronoun), an interrogative or relative pronoun
* Who?, one of the Five Ws in journalism
* World Health Organization
Arts and entertainment Fictional characters
* Who, a creature in the Dr. Seuss book ''Horton Hear ...
Expert Panel on Virus Diseases and the International Committee on Taxonomy of Viruses
The International Committee on Taxonomy of Viruses (ICTV) authorizes and organizes the taxonomic classification of and the nomenclatures for viruses. The ICTV has developed a universal taxonomic scheme for viruses, and thus has the means to app ...
, as well as numerous committees and expert panels for US national bodies including the Institute of Medicine, National Institutes of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
and National Research Council National Research Council may refer to:
* National Research Council (Canada), sponsoring research and development
* National Research Council (Italy), scientific and technological research, Rome
* National Research Council (United States), part of ...
. He was one of the co-editors of ''Fields Virology
''Fields Virology'' is an English-language virology textbook, originally it was published in two volumes and edited by Bernard N. Fields. The first edition in 1985 was called ''Virology'', but from the second edition, the book's title was changed ...
'', the "definitive" virology text.
Personal life
Shope was married to Virginia; the couple had two sons (Peter and Steven) and two daughters (Deborah and Bonnie). He had idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), or (formerly) fibrosing alveolitis, is a rare, progressive illness of the respiratory system, characterized by the thickening and stiffening of lung tissue, associated with the formation of scar tissue. It is ...
, for which he received a lung transplant
Lung transplantation, or pulmonary transplantation, is a surgical procedure in which one or both lungs are replaced by lungs from a donor. Donor lungs can be retrieved from a living or deceased donor. A living donor can only donate one lung lobe. ...
in December 2003. He died the following month in Galveston, from complications from the operation, at the age of 74.
Societies, awards and honours
Shope served as president of the American Society of Tropical Medicine and Hygiene
The American Society of Tropical Medicine and Hygiene (ASTMH) is an Arlington, Virginia-based non-profit organization of scientists, clinicians, students and program professionals whose longstanding mission is to promote global health through the ...
(ASTMH) in 1980. He was awarded the society's Bailey K. Ashford Medal (1974), Richard M. Taylor Award (1987) and Walter Reed Medal (1993). In 2005, ASTMH established the Robert E. Shope International Fellowship in Infectious Diseases in his memory. The University of Texas Medical Branch named its biosafety level 4 laboratory, completed just before his death, The Robert E. Shope, M.D. Laboratory, and also set up a fellowship in his memory. A symposium was held in his honour on March 18–21, 2004.
References
{{DEFAULTSORT:Shope, Robert
1929 births
2004 deaths
American virologists
American public health doctors
People from Princeton, New Jersey
Cornell University alumni
Yale School of Medicine faculty
University of Texas Medical Branch faculty
United States Army Medical Corps officers
Military personnel from New Jersey
Presidents of the American Society of Tropical Medicine and Hygiene