Ro 3-0419 is a highly toxic

organophosphate In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered a ...

acetylcholinesterase inhibitor Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and ...

. It is the neutral analog of

Ro 3-0422 Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous is 20 μg/kg in mice. It is over 300 times more potent than neostigmine Neostigmine, sold under the brand name Bloxiverz ...

. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, resulting in its ability to cross the

blood brain barrier Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the Cell (biology), cells, and transports Metabolic waste, metabolic waste products away from th ...

to inhibit cholinesterases in the brain. The intravenous of Ro 3-0419 is 1 mg/kg in mice.

References

Acetylcholinesterase inhibitors Organophosphates Quinolines Ethyl esters {{Organic-compound-stub

See also

References